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Published Online: July 1945

AMNESTIC-CONFABULATORY SYNDROME (KORSAKOFF PSYCHOSIS) FOLLOWING HEAD INJURY

ARNOLD P. FRIEDMAN and CHARLES BRENNERAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 102, Number 1

https://doi.org/10.1176/ajp.102.1.61

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Abstract

1. Of a total of 430 patients with head injury, 40 had prolonged confusion following the injury, and of these 9 showed amnestic-confabulatory syndrome during their hospital stay. None of the 9 showed evidence of polyneuritis.

2. All 9 patients were males and 5 (55 percent) were chronic alcoholics prior to injury. This is in contrast with the 21 percent incidence of alcoholism in the group as a whole. In addition 2 others were steady but "moderate" drinkers and there was some suspicion of alcoholism in the 2 remaining. One of these received large amounts of paraldehyde in the 3½ months after injury prior to the development of an amnestic-confabulatory syndrome.

3. All 9 patients recovered. The duration of the amnestic-confabulatory syndrome varied from 2 to 44 days (average 11 days). This is in striking contrast to the grave prognosis in patients with amnestic-confabulatory syndrome with polyneuritis.

4. As a group the patients who developed amnestic-confabulatory syndrome suffered relatively severe injuries to cranial contents as judged by presence of abnormal neurological signs, presence of blood in the cerebrospinal fluid, and duration of permanent post-traumatic amnesia. However, many other patients with equally severe injuries failed to develop the amnestic-confabulatory syndrome.

5. There was no clear relationship between duration of amnestic-confabulatory syndrome and the maximum cerebrospinal fluid pressure as determined by lumbar puncture, or the presence of extensor plantar responses. The 2 patients without blood in their cerebrospinal fluid had the briefest duration of amnestic-confabulatory syndrome (2-5 days).

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 102 • Number 1 • July 1945

Pages: 61 - 66

History

Published in print: July 1945

Published online: 1 April 2006

Authors

Affiliations

ARNOLD P. FRIEDMAN

The Neurological Unit of the Boston City Hospital and the Department of Neurology of the Harvard Medical School.

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CHARLES BRENNER

The Neurological Unit of the Boston City Hospital and the Department of Neurology of the Harvard Medical School.

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AMNESTIC-CONFABULATORY SYNDROME (KORSAKOFF PSYCHOSIS) FOLLOWING HEAD INJURY

Abstract

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