No access

Article

Published Online: February 1957

SOME HYPOTHESES CONCERNING THE ROLE OF SYMPATHOMIMETIC AMINES IN PSYCHIATRIC CONDITIONS

SOLOMON GARB, NATHURAM M. TIWARI, and LORING F. CHAPMANAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 113, Number 8

https://doi.org/10.1176/ajp.113.8.740

Get Access

Abstract

The following hypotheses are suggested concerning the possible roles of sympathomimetic amines in psychiatric conditions:

1. Isuprel, or a similar substance, may be an important chemical mediator in anxiety.

2. Another amine, possibly nor-epinephrine, may be an important chemical mediator in aggression and hostility.

3. When a patient experiences approximately equal quantities of hostility and anxiety, equipotent concentrations of Isuprel and the other amine may be liberated, producing depression, by a mechanism similar to that whereby a mixture of 2 amines depresses the isolated mammalian auricle, although either amine alone has a stimulant action.

An additional possibility suggested by continuing studies in this field is that the depression of rate and force observed with the mixture of amines is produced by an intermediate metabolite, formed within 1 or 2 minutes.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 113 • Number 8 • February 1957

Pages: 740 - 743

PubMed: 13394750

History

Published in print: February 1957

Published online: 1 April 2006

Authors

Details

SOLOMON GARB

The Department of Pharmacology, Cornell University Medical College, 1300 York Ave., New York 21, N. Y.

View all articles by this author

NATHURAM M. TIWARI

The Department of Pharmacology, Cornell University Medical College, 1300 York Ave., New York 21, N. Y.

View all articles by this author

LORING F. CHAPMAN

The Department of Pharmacology, Cornell University Medical College, 1300 York Ave., New York 21, N. Y.

View all articles by this author

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

View Options

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

SOME HYPOTHESES CONCERNING THE ROLE OF SYMPATHOMIMETIC AMINES IN PSYCHIATRIC CONDITIONS

Abstract

Get full access to this article