IPRONIAZID CHEMOTHERAPY IN MELANCHOLIA

THEODORE R. ROBIEAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 115, Number 5

https://doi.org/10.1176/ajp.115.5.402

Get Access

Abstract

1. Chemotherapeutic remission of melancholia can now be accomplished, in a majority of cases, without resort to ECT, by carefully supervised administration of Marsilid, Roche iproniazid (1-isonicotinyl, 2-isopropylhydrazine phosphate).

2. However, until methods are discovered for accelerating Marsilid's effectiveness in the first few days of treatment, the aggressively suicidal case must still be given ECT, which assures most immediate remission of depression. Each case must be carefully evaluated when first seen.

3. This chemical, introduced 6 years ago for the treatment of tuberculosis, is now found to possess much wider scope in medicine including therapeutic efficacy in some apathetic and withdrawn, seclusive types.

4. A major factor in the effectiveness of this chemical in accomplishing psychic energization is the prevention of inactivation of the brain-stored powerful hormone serotonin, by its amine oxidase inhibitor action, but other equally powerful chemical Interactions may be simultaneously involved.

5. The powerful chemical forces released may Induce serious complications unless the physician psychiatrist is constantly alert to the need for frequent alteration of dosage as indicated by his physical findings.

6. Excellent antidotes for certain complications are available.

7. A by-product of major significance is the enhancement of psychotherapy through increased spontaneity, improved sense of well being and resulting betterment of rapport.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 115 • Number 5 • November 1958

Pages: 402 - 409

PubMed: 13583240

History

Published in print: November 1958

Published online: 1 April 2006

Authors

Details

THEODORE R. ROBIE

View all articles by this author

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

View Options

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

IPRONIAZID CHEMOTHERAPY IN MELANCHOLIA

Abstract

Get full access to this article