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Published Online: November 1959

A GRAPHIC COMPARISON OF FIVE PHENOTHIAZINES

JACKSON A. SMITH, DOROTHY CHRISTIAN, ELAINE MANSFIELD, and ALFREDO FIGAREDOAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 116, Number 5

https://doi.org/10.1176/ajp.116.5.392

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Abstract

Five phenothiazine derivatives have been studied using similar groups of patients and similar methods of evaluating and recording behavioral change. All of the patients included in these reports had been hospitalized longer than one year and had been refractory to previous treatment efforts.

The results indicate that this group of chronic patients, all but 3 of whom were schizophrenic, were no more responsive to these compounds than to treatment procedures earlier tried. The graphing of the data simplifies the comparison of compounds evaluated under similar conditions.

Improvement occurred so infrequently in these screening procedures that a controlled or "double-blind" study did not appear necessary.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 116 • Number 5 • November 1959

Pages: 392 - 399

PubMed: 13831998

History

Published in print: November 1959

Published online: 1 April 2006

Authors

Details

JACKSON A. SMITH

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DOROTHY CHRISTIAN

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ELAINE MANSFIELD

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ALFREDO FIGAREDO

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Professor of Neurology and Psychiatry, Univ. of Neb. College of Medicine, Associate Director for Research, Neb. Psychiatric Inst., Omaha, Neb.

Research Nurse, Norfolk State Hosp., Norfolk, Neb.

Chief Research Nurse, and Resident, Nebraska Psychiatric Institute, Omaha, Neb.

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A GRAPHIC COMPARISON OF FIVE PHENOTHIAZINES

Abstract

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