CLINICAL EVALUATION OF A NEW PHENOTHIAZINE TRANQUILIZER, FLUPHENAZINE (PROLIXIN)

IRVING J. TAYLORAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 116, Number 5

https://doi.org/10.1176/ajp.116.5.457

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Abstract

Of the patients treated with fluphenazine, 141 of the 166 who were evaluated (85%) improved, 23 responded poorly, and 24 were for appropriate reasons not evaluated. The average dose was 5 mg. on admission, 5 mg. the next morning and 2.5 mg. thereafter as a single morning dose. Extrapyramidal effects were seen in patients receiving higher doses (5 to 10 mg. daily) but these were controllable by reducing the dosage.

Fluphenazine is an effective tranquilizer and is the most potent of the phenothiazines previously employed here, being about 25 times as potent as chlorpromazine. The rapid and sustained action of the drug and its administration as a single daily dose are distinctly advantageous.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 116 • Number 5 • November 1959

Pages: 457 - 458

PubMed: 13837157

History

Published in print: November 1959

Published online: 1 April 2006

Authors

Details

IRVING J. TAYLOR

Taylor Manor Hospital, Ellicott City, Md.

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CLINICAL EVALUATION OF A NEW PHENOTHIAZINE TRANQUILIZER, FLUPHENAZINE (PROLIXIN)

Abstract

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