IMPROVING INSULIN THERAPY WITH NEOSTIGMINE

In insulin coma therapy, in those patients who regularly require intravenous injections of glucose to bring them out of coma, the intramuscular injection of 1 or 1½ mg. of neostigmine from 10 to 45 minutes before gavage with 1 quart of 40% sucrose resulted in a 100% elimination of intravenous injections required. This therefore is felt to be an important contribution to insulin coma therapy. In addition it may help materially in the re-establishment of insulin coma therapy at those mental hospitals where it was previously discontinued because of the greater number of personnel required to administer intravenous injections.