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Article

Published Online: November 1960

STEPS TOWARD THE ISOLATION OF A SERUM FACTOR IN SCHIZOPHRENIA

CHARLES FROHMAN, ELLIOT D. LUBY, GARFIELD TOURNEY, PETER G. S. BECKETT, and JACQUES S. GOTTLIEBAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 117, Number 5

https://doi.org/10.1176/ajp.117.5.401

Abstract

1. The steps in the separation of a factor in the serum of schizophrenic patients have been described.

2. This factor has a significant effect on metabolism as measured by lactate/pyruvate ratios in the chicken erythrocyte and the stimulation of energy production by forcing glucose through the Emden-Meyerhof scheme, rather than the hexosemonophosphate shunt.

3. This factor is readily affected by pH and temperature, remaining relatively stable between pH 6 and 9 at 4° C. It is probable that this is an alpha globulin or a prosthetic group attached to an alpha globulin.

4. The significance of this factor for the schizophrenic illness has not yet been clarified. This may be a substance normally present in the serum of all individuals, but quantitatively elevated in the schizophrenic because of excessive production or its failure to be metabolized or detoxified. On the other hand, this may be a qualitatively abnormal substance characteristic of schizophrenia.

5. The possible relationship of this factor to other reported toxic factors in schizophrenia has been discussed.

6. Further biochemical studies are in progress to identify the subject, as well as behavioral studies to ascertain its relationship to the production of disturbances in overt behavior.

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Information

Published In

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Go to American Journal of Psychiatry

American Journal of Psychiatry

Volume 117 • Number 5 • November 1960

Pages: 401 - 408

PubMed: 13702195

History

Published in print: November 1960

Published online: 1 April 2006

Authors

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CHARLES FROHMAN

Lafayette Clinic, Detroit, Mich. and Wayne State University, College of Medicine.

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ELLIOT D. LUBY

Lafayette Clinic, Detroit, Mich. and Wayne State University, College of Medicine.

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GARFIELD TOURNEY

Lafayette Clinic, Detroit, Mich. and Wayne State University, College of Medicine.

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PETER G. S. BECKETT

Lafayette Clinic, Detroit, Mich. and Wayne State University, College of Medicine.

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JACQUES S. GOTTLIEB

Lafayette Clinic, Detroit, Mich. and Wayne State University, College of Medicine.

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