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Published Online: September 1970

Perphenazine-Amitriptyline in Neurotic Depressed Outpatients: A Controlled Collaborative Study

ROBERT V. DESILVERIO, KARL RICKELS, CHARLES C. WEISE, EDWARD L. CLARK, and JAMES HUTCHINSONAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 127, Number 3

https://doi.org/10.1176/ajp.127.3.322

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Abstract

The combination of perphenazine-amitriptyline was compared to each of its constituents in a double-blind study conducted with 138 depressed and anxious-depressed neurotic outpatients. Irrespective of drug, general practice patients improved the most, clinic patients somewhat less, and private psychiatric patients the least. Drug differences were limited to a few significant and borderline-significant effects present only at two weeks; they indicated that perphenazine produced the greatest improvement at this period.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 127 • Number 3 • September 1970

Pages: 322 - 329

PubMed: 4917854

History

Published in print: September 1970

Published online: 1 April 2006

Authors

Affiliations

ROBERT V. DESILVERIO

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KARL RICKELS

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CHARLES C. WEISE

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EDWARD L. CLARK

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JAMES HUTCHINSON

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Assistant director of psychopharmacology, Philadelphia General Hospital

Professor of psychiatry, University of Pennsylvania, 203 Piersol Bldg., 3400 Spruce St., Philadelphia, Pa. 19104, and director of psychopharmacology, Philadelphia General Hospital

Private practice and is member of the private practice research group, University of Pennsylvania

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Perphenazine-Amitriptyline in Neurotic Depressed Outpatients: A Controlled Collaborative Study

Abstract

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