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Published Online: February 1971

Effectiveness of Antidepressant Drugs: A Triple-Blind Study Comparing Imipramine, Desipramine, and Placebo

ABRAHAM HELLER, RORRY ZAHOUREK, and H. G. WHITTINGTONAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 127, Number 8

https://doi.org/10.1176/ajp.127.8.1092

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Abstract

The authors made a triple-blind comparison of placebo, imipramine, and desipramine in severely depressed hospitalized psychiatric patients. They found that both drugs were superior to placebo, that imipramine was the drug of choice in treating these patients, and that imipramine was superior to desipramine and placebo in the rapidity of action and in the degree of improvement noted.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 127 • Number 8 • February 1971

Pages: 1092 - 1095

PubMed: 4925145

History

Published in print: February 1971

Published online: 1 April 2006

Authors

Affiliations

ABRAHAM HELLER

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RORRY ZAHOUREK

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H. G. WHITTINGTON

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Director, Community Mental Health Center, Department of Health and Hospitals, W. Sixth Ave. and Cherokee St., Denver, Cob. 80204

Psychiatric Research Nurse, Community Mental Health Center, Department of Health and Hospitals, W. Sixth Ave. and Cherokee St., Denver, Cob. 80204

Director of Psychiatric Services, Community Mental Health Center, Department of Health and Hospitals, W. Sixth Ave. and Cherokee St., Denver, Cob. 80204

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Effectiveness of Antidepressant Drugs: A Triple-Blind Study Comparing Imipramine, Desipramine, and Placebo

Abstract

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