Safety of High-Dose Tricyclic Antidepressant Therapy

MARC A. SCHUCKIT and JOHN P. FEIGHNERAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 128, Number 11

https://doi.org/10.1176/ajp.128.11.1456

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Abstract

The authors report on a series of depressed inpatients and outpatients who received greater-than-recommended doses of the tricyclic antidepressants for 1,505 patient days. These patients tolerated the drugs with a minimum of side effects and, when tested, showed no evidence of hematologic, hepatic, or ocular damage. The authors give some possible explanations for the individual variations in tolerance and response to this high-dose regimen.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 128 • Number 11 • May 1972

Pages: 1456 - 1459

PubMed: 5020200

History

Published in print: May 1972

Published online: 1 April 2006

Authors

Affiliations

MARC A. SCHUCKIT

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JOHN P. FEIGHNER

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Chief Resident, Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla, Calif. 92037

Assistant Clinical Professor, Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla, Calif. 92037

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Safety of High-Dose Tricyclic Antidepressant Therapy

Abstract

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