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Published Online: July 1972

Lithium Response in Unipolar Versus Bipolar Depression

FREDERICK K. GOODWIN, DENNIS L. MURPHY, DAVID L. DUNNER, and WILLIAM E. BUNNEY, JR.Authors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 129, Number 1

https://doi.org/10.1176/ajp.129.1.44

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Abstract

The antidepressant effects of lithium carbonate were evaluated in a group of 52 hospitalized depressed patients, using a longitudinal double-blind design that involved alternating drug and placebo periods in the same patient. Thirty-six of the 52 patients showed some improvement on lithium, including 15 who had complete remission of symptoms. Virtually all of the antidepressant responses occurred in patients with a past history of mania or hypomania (the bipolar group).

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 129 • Number 1 • July 1972

Pages: 44 - 47

PubMed: 4556087

History

Published in print: July 1972

Published online: 1 April 2006

Authors

Affiliations

FREDERICK K. GOODWIN

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DENNIS L. MURPHY

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DAVID L. DUNNER

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WILLIAM E. BUNNEY, JR.

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New York State Psychiatric Institute, New York, N.Y.

Director, Division of Narcotic Addiction and Drug Abuse, NIMH

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Lithium Response in Unipolar Versus Bipolar Depression

Abstract

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