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Published Online: January 1973

L-Dopa, Dopamine, and Hypomania

DENNIS L. MURPHY, FREDERICK K. GOODWIN, H. KEITH H. BRODIE, and WILLIAM E. BUNNEY, JR.Authors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 130, Number 1

https://doi.org/10.1176/ajp.130.1.79

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Abstract

Greater urinary excretion of dopamine during L-dopa administration was observed in bipolar than in unipolar depressed patients. The authors suggest that increased levels of brain dopamine may play a role in the development of hypomania and mania, since there is a tendency for bipolar patients to regularly develop hypomanic episodes during L-dopa treatment and since evidence from animal studies indicates that increased brain dopamine is highly correlated with increased psychomotor activity.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 130 • Number 1 • January 1973

Pages: 79 - 82

PubMed: 4682751

History

Published in print: January 1973

Published online: 1 April 2006

Authors

Details

DENNIS L. MURPHY

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FREDERICK K. GOODWIN

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H. KEITH H. BRODIE

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WILLIAM E. BUNNEY, JR.

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Clinical Research Unit Chief, Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md.

Assistant Professor of Psychiatry, Stanford University Medical School, Stanford, Calif.

Director, Division of Narcotics and Drug Abuse, NIMH

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L-Dopa, Dopamine, and Hypomania

Abstract

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