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Published Online: July 1973

Antagonism of Guanethidine by Chlorpromazine

DAVID S. JANOWSKY, M. KHALED EL-YOUSEF, JOHN M. DAVIS, and WILLIAM E. FANNAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 130, Number 7

https://doi.org/10.1176/ajp.130.7.808

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Abstract

Chlorpromazine was found to reverse the antihypertensive effects of guanethidine six times in use with four moderately or severely hypertensive psychiatric patients. Haloperidol and thiothixene caused similar effects. It is postulated that this drug-drug interaction occurs because chlorpromazine blocks the neuronal amine-guanethidine uptake pump, thereby denying guanethidine access to its site of action.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 130 • Number 7 • July 1973

Pages: 808 - 812

PubMed: 4712739

History

Published in print: July 1973

Published online: 1 April 2006

Authors

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DAVID S. JANOWSKY

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M. KHALED EL-YOUSEF

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JOHN M. DAVIS

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WILLIAM E. FANN

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Associate Professor of Psychiatry and Assistant Professor of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. 37203

Assistant Professor of Psychiatry and Instructor of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. 37203

Professor of Psychiatry and Assistant Professor of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. 37203

Associate Professor of Psychiatry, Duke University School of Medicine, Durham, N.C.

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Antagonism of Guanethidine by Chlorpromazine

Abstract

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