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Research Article
Published Online: June 1975

The relationship between hiatus hernia and tricyclic antidepressants: a report of five cases

Publication: American Journal of Psychiatry

Abstract

Of five patients who were receiving tricyclic antidepressants, two experienced an aggravation of preexisting hiatus hernia, and three with previously normal gastrointestinal X rays developed hiatal herination. The author suggests that this group of drugs may exert an anticholinergic effect on the esophageal sphincter and reduce the tone of the esophagogastric sphincter, thus aggravating existing hiatus hernia or causing its development.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 652 - 653
PubMed: 1124813

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Published in print: June 1975
Published online: 1 April 2006

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