Evaluating antianxiety agents in humans: experimental paradigms

Publication: American Journal of Psychiatry

https://doi.org/10.1176/ajp.134.6.659

Abstract

Conventional clinical trials using parallel groups are relatively insensitive to the effects of psychotropic drugs, especially antianxiety agents. Experimental paradigms based on the single organism research strategy offer an alternative. A free operant avoidance procedure clearly distinguished representative psychotropic compounds, including diazepam and pentobarbital, in normal subjects, and a multiple crossover procedure clearly detected antianxiety effects of diazepam in 11 psychoneurotic patients and antipsychotic effects of chlordiazepoxide in individual schizophrenic patients. Such procedures may serve to evaluate the effectiveness of therapeutic interventions in clinical practice as well as in research.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 134 • Number 6 • June 1977

Pages: 659 - 662

PubMed: 869031

History

Published in print: June 1977

Published online: 1 April 2006

Authors

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

View Options

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Evaluating antianxiety agents in humans: experimental paradigms

Abstract

Get full access to this article