Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression

Publication: American Journal of Psychiatry

https://doi.org/10.1176/ajp.135.5.562

Abstract

Five of 8 patients with unipolar or bipolar endogenous depressions taking prolyl-leucyl-glycinamide (MIF-I), 75 mg/day, showed substantial improvement within a few days of beginning treatment compared with similar improvement in only 1 of 10 receiving 750 mg/day of MIF-I and only 1 of 5 patients taking placebo. The lower dose of MIF-I was associated with significantly greater improvement than both the higher dose and placebo on all of the rating scales used. The authors suggest that an even lower dose of MIF-I, on the order of 0.1 mg/kg, may have a greater effect as an antidepressant.

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Published In

American Journal of Psychiatry

Volume 135 • Number 5 • May 1978

Pages: 562 - 566

PubMed: 25588

History

Published in print: May 1978

Published online: 1 April 2006

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Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression

Abstract

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