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Research Article
Published Online: May 1992

Abnormal diurnal variation in circulating natural killer cell phenotypes and cytotoxic activity in major depression

Publication: American Journal of Psychiatry

Abstract

This investigation tested the hypothesis that depressed patients have abnormal diurnal variation of natural killer (NK) cell measures. The diurnal variation of levels of Leu-11 NK cells and NK cytotoxic activity was significantly less in 24 patients with major depression than in 24 normal comparison subjects. These findings provide evidence that aspects of immune, as well as neural and endocrine, chronobiology are abnormal in depression.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 694 - 696
PubMed: 1533492

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Published in print: May 1992
Published online: 1 April 2006

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