Cholinesterase Inhibitors: A New Class of Psychotropic Compounds
Abstract
CENTRAL CHOLINERGIC SYSTEMS
Anatomy of the Cholinergic System
Cholinergic Receptors
Acetylcholinesterase
CHOLINERGIC ABNORMALITIES IN ALZHEIMER’S DISEASE
CLASSES OF CHOLINESTERASE INHIBITORS
BEHAVIORAL RESPONSES TO CHOLINESTERASE INHIBITORS
Physostigmine
Tacrine
Velnacrine
Donepezil
Metrifonate
Eptastigmine
Rivastigmine
DISCUSSION
Neurobiological Basis of the Response to Cholinergic Agents
Neurobiological Basis of Variations in Response to Cholinergic Therapy
Relationship of Behavioral and Cognitive Changes
Regulatory Issues
Clinical Importance
Role of Cholinergic Therapy in Other Conditions
Behavioral Effects of Cholinergic Agonists
Summary
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