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Published Online: December 1974

Catecholamine Receptor Function in Depressed Patients

Abstract

The authors compared the effects of norepinephrine on catecholamine alpha receptors in platelets obtained from bipolar and unipolar depressed patients and from normal subjects. They found no differences, although reduced catecholamine receptor function has been suggested as one specific mechanism to account for a deficit in catecholamine function in depression.

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Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 1389 - 1391
PubMed: 4372899

History

Published in print: December 1974
Published online: 24 April 2020

Authors

Affiliations

Dennis L. Murphy, M.D.
Dr. Murphy is Chief, Section on Clinical Neuropharmacology, and Ms Donnelly is Chemist, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. Ms Donnelly is also a graduate student, Department of Chemistry, University of Maryland, College Park, Md. At the time this work was done, Dr. Moskowitz was Research Associate in the Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Md. He is currently Chief, Special Programs and Resources Branch, Division of Lung Diseases, National Heart and Lung Institute, Bethesda, Md. Address reprint requests to Dr. Murphy, NIH Clinical Center, Building 10, Room 3S229, 9000 Rockville Pike, Bethesda, Md. 20014.
Cynthia Donnelly
Dr. Murphy is Chief, Section on Clinical Neuropharmacology, and Ms Donnelly is Chemist, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. Ms Donnelly is also a graduate student, Department of Chemistry, University of Maryland, College Park, Md. At the time this work was done, Dr. Moskowitz was Research Associate in the Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Md. He is currently Chief, Special Programs and Resources Branch, Division of Lung Diseases, National Heart and Lung Institute, Bethesda, Md. Address reprint requests to Dr. Murphy, NIH Clinical Center, Building 10, Room 3S229, 9000 Rockville Pike, Bethesda, Md. 20014.
Jay Moskowitz, PH.D.
Dr. Murphy is Chief, Section on Clinical Neuropharmacology, and Ms Donnelly is Chemist, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. Ms Donnelly is also a graduate student, Department of Chemistry, University of Maryland, College Park, Md. At the time this work was done, Dr. Moskowitz was Research Associate in the Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Md. He is currently Chief, Special Programs and Resources Branch, Division of Lung Diseases, National Heart and Lung Institute, Bethesda, Md. Address reprint requests to Dr. Murphy, NIH Clinical Center, Building 10, Room 3S229, 9000 Rockville Pike, Bethesda, Md. 20014.

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