Pharmacokinetic Determinants of the Response to Single Doses of Chlordiazepoxide

David J. Greenblatt, M.D., Richard I. Shader, M.D., and Jan Koch-Weser, M.D.Authors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 131, Number 12

https://doi.org/10.1176/ajp.1974.131.12.1395

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Abstract

Blood concentrations of the minor tranquilizer chlordiazepoxide were measured in nine healthy volunteers after administration of single 25-mg. doses. Peak blood concentrations and rates of absorption and disappearance varied considerably among the subjects. Such pharmacokinetic variations have important clinical consequences and probably contribute to individual differences in the response to minor tranquilizers.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 131 • Number 12 • December 1974

Pages: 1395 - 1397

PubMed: 4432941

History

Published in print: December 1974

Published online: 24 April 2020

Authors

Affiliations

David J. Greenblatt, M.D.

Dr. Greenblatt is Assistant in Medicine (Clinical Pharmacology) and Dr. Koch-Weser is Chief, Clinical Pharmacology Unit, Massachusetts General Hospital, Boston, Mass. 02114. Dr. Shader is Director of Clinical Psychiatry and Director of the Psychopharmacology Research Laboratory, Massachusetts Mental Health Center, Boston, Mass. All of the authors are also with Harvard Medical School, Boston, Mass., where Dr. Greenblatt is Assistant Professor of Medicine (Clinical Pharmacology), Dr. Shader is Associate Professor of Psychiatry, and Dr. KochWeser is Associate Professor of Pharmacology. Address reprint requests to Dr. Greenblatt.

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Richard I. Shader, M.D.

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Jan Koch-Weser, M.D.

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Pharmacokinetic Determinants of the Response to Single Doses of Chlordiazepoxide

Abstract

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