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Published Online: April 1979

A Possible Cardiovascular Effect of Lithium

Robert H. Belmaker, M.D., Rachel Lehrer, Richard P. Ebstein, PH.D., Haya Lettik, and Sol Kugelmass, PH.D.Authors Info & Affiliations
Publication: American Journal of Psychiatry
Volume 136, Number 4B
https://doi.org/10.1176/ajp.1979.136.4b.577
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Abstract

Heart rate rises associated with performance of mental arithmetic tasks were compared in 22 euthymic manic-depressive patients receiving lithium carbonate and 17 drug-free normal controls. The lithium-treated subjects showed a markedly lower heart rate response to the mental arithmetic stimulus. No effect was observed on basal heart rate. The results are consistent with lithium’s reported inhibition of noradrenaline-induced rises in adenylate cyclase activity but lack of inhibition of basal adenylate cyclase activity. The biochemical and psychophysiological findings may parallel lithium’s unique ability to calm excited behavior without sedating normal behavior.

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Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Volume 136 • Number 4B • April 1979
Pages: 577 - 579
PubMed: 218467

History

Received: 18 October 1977
Revised: 21 March 1978
Accepted: 30 March 1978
Published in print: April 1979
Published online: 24 April 2020

Authors

Details

Robert H. Belmaker, M.D.
Dr. Belmaker is Director, and Dr. Ebstein is Senior Scientist, Department of Research, Jerusalem Mental Health Center-Ezrath Nashim, Jerusalem. Dr. Kugelmass is Professor of Psychology, and Ms. Lehrer and Ms. Lettik are graduate students in psychology, Department of Psychology, Hebrew University, Jerusalem. Address reprint requests to Dr. Belmaker at Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel.
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Rachel Lehrer
Dr. Belmaker is Director, and Dr. Ebstein is Senior Scientist, Department of Research, Jerusalem Mental Health Center-Ezrath Nashim, Jerusalem. Dr. Kugelmass is Professor of Psychology, and Ms. Lehrer and Ms. Lettik are graduate students in psychology, Department of Psychology, Hebrew University, Jerusalem. Address reprint requests to Dr. Belmaker at Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel.
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Richard P. Ebstein, PH.D.
Dr. Belmaker is Director, and Dr. Ebstein is Senior Scientist, Department of Research, Jerusalem Mental Health Center-Ezrath Nashim, Jerusalem. Dr. Kugelmass is Professor of Psychology, and Ms. Lehrer and Ms. Lettik are graduate students in psychology, Department of Psychology, Hebrew University, Jerusalem. Address reprint requests to Dr. Belmaker at Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel.
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Haya Lettik
Dr. Belmaker is Director, and Dr. Ebstein is Senior Scientist, Department of Research, Jerusalem Mental Health Center-Ezrath Nashim, Jerusalem. Dr. Kugelmass is Professor of Psychology, and Ms. Lehrer and Ms. Lettik are graduate students in psychology, Department of Psychology, Hebrew University, Jerusalem. Address reprint requests to Dr. Belmaker at Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel.
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Sol Kugelmass, PH.D.
Dr. Belmaker is Director, and Dr. Ebstein is Senior Scientist, Department of Research, Jerusalem Mental Health Center-Ezrath Nashim, Jerusalem. Dr. Kugelmass is Professor of Psychology, and Ms. Lehrer and Ms. Lettik are graduate students in psychology, Department of Psychology, Hebrew University, Jerusalem. Address reprint requests to Dr. Belmaker at Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel.
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