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Published Online: November 1940

HUMAN BRAIN METABOLISM : Normal Values and Values in Certain Clinical States.

JOSEPH WORTIS, KARL M. BOWMAN, and WALTER GOLDFARBAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 97, Number 3

https://doi.org/10.1176/ajp.97.3.552

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Abstract

The metabolism of the brain was studied in normal, schizophrenic, paretic and senile subjects, and the effect of alcohol, paraldehyde and morphine was studied. Arterio-venous differences for oxygen, carbon dioxide, glucose and lactic acid were determined by means of internal jugular puncture. The observations support the following conclusions:

1. The O₂ arterio-venous difference of the brain in schizophrenics, both before and after insulin therapy, is normal.

2. In general paresis the O₂ arterio-venous difference of the brain shows a slight diminution of questionable significance.

3. The O₂ arterio-venous difference of the brain in patients with cerebral arteriosclerosis is normal, but their systemic circulation is somewhat slow. This would indicate a reduced brain metabolism.

4. The O₂ arterio-venous difference in chronic alcoholism tends to be higher than normal and is associated with an elevated arterial glucose level.

5. Alcohol and morphine diminish the O₂ arterio-venous difference of the brain.

6. In therapeutic doses paraldehyde did not diminish the O₂ arterio-venous difference of the brain of chronic alcoholic patients.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 97 • Number 3 • November 1940

Pages: 552 - 565

History

Published in print: November 1940

Published online: 1 April 2006

Authors

Affiliations

JOSEPH WORTIS

The Psychiatric Division of Bellevue Hospital, and the Department of Psychiatry, New York University College of Medicine, New York, N. Y.

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KARL M. BOWMAN

The Psychiatric Division of Bellevue Hospital, and the Department of Psychiatry, New York University College of Medicine, New York, N. Y.

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WALTER GOLDFARB

The Psychiatric Division of Bellevue Hospital, and the Department of Psychiatry, New York University College of Medicine, New York, N. Y.

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HUMAN BRAIN METABOLISM : Normal Values and Values in Certain Clinical States.

Abstract

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