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Letter to the Editor
Published Online: 1 December 2002

New-Onset PTSD After Thalamic Infarct

To the Editor: The onset of symptoms of posttraumatic stress disorder (PTSD) and the reawakening of old traumatic memories after brain injury have been cited (1); there are anecdotal reports relating thalamic dysfunction to PTSD on neuroimaging (13). However, as there are no reports, to our knowledge, of PTSD as a sequel of a thalamic lesion, a similar case is described.
Mr. A, a 70-year-old Korean War veteran with a history of hypertension, was treated for a pure sensory stroke after a lacunar infarct in the left posterior thalamus. Although his sensory symptoms gradually improved, a year after the stroke he started losing interest in his hobbies and became aloof. However, he reported no other depressive symptoms. Four months later, Mr. A suddenly started experiencing repetitive thoughts about a colleague’s suicide, which he had witnessed in 1953. This colleague, although not Mr. A’s buddy or close friend, had the same rank as Mr. A and shared the same dormitory.
Mr. A began feeling anxious and jittery and had difficulty falling asleep. He was startled by the ring of the telephone and began avoiding television programs displaying war scenes. No depressive cognitions, obsessions, flashbacks, delusions, or hallucinations were elicited. His family history was unremarkable, and so was his past psychiatric history, including that for PTSD symptoms, such as reexperiencing, avoidance, or hyperarousal. There was no history of recent trauma or stressors, and he had never thought about this incident before. A repeat cranial computerized tomography scan showed no new findings. Mr. A was diagnosed with PTSD with delayed onset.
This case provides an opportunity to study the role of thalamic amygdalar and thalamic cortical pathways in PTSD. After a brain infarct, there is a surge in glutamate (4), which in turn increases glutamatergic transmission in the thalamic amygdalar pathway (5). Of interest, this pathway is involved in long-term potentiation, which induces plastic changes in the amygdala; the amygdala is involved in fear conditioning and in the processing of traumatic memories (5). Moreover, with the infarction of the left thalamus, there could be a partial disconnection in the thalamic cortical connection, which would parallel the functional dissociation between the thalamus and cortex during sleep. Hippocampal cells have been shown to have a higher rate of synchronous discharge during this phase, which contributes to memory consolidation (6). Thus, integrating these observations, one can hypothesize that the possible thalamic cortical disconnection, with its resultant greater availability of hippocampal information, compounded by an enhanced thalamic amygdalar transmission, may contribute to a greater conscious awareness of old, unwanted traumatic memories.
This notion is supported by the role of thalamic-cortical connections in modulating the content of consciousness (7). Moreover, thalamic hypofunction in PTSD has been shown in a recent functional neuroimaging study (3), while two individual case reports have indicated greater thalamic activity in PTSD (1, 2). Thus, future studies are needed to clarify the role of the thalamus in PTSD. Finally, the role of glutamate in PTSD, as highlighted previously (4), deserves further exploration.

References

1.
Berthier ML, Posada A, Puentes C: Dissociative flashbacks after right frontal injury in a Vietnam veteran with combat-related posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci 2001; 13:101-105
2.
Liberzon I, Taylor SF, Fig LM, Koeppe RA: Alteration of corticothalamic perfusion ratios during a PTSD flashback. Depress Anxiety 1996-1997; 4:146-150
3.
Lanius RA, Williamson PC, Densmore M, Boksman K, Gupta MA, Neufeld RW, Gati JS, Menon RS: Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation. Am J Psychiatry 2001; 158:1920-1922
4.
Chambers RA, Bremner JD, Moghaddam B, Southwick SM, Charney DS, Krystal JH: Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Semin Clin Neuropsychiatry 1999; 4:274-281
5.
Ledoux JE, Muller J: Emotional memory and psychopathology. Philos Trans R Soc Lond B Biol Sci 1997; 352:1719-1726
6.
Steriade M: Corticothalamic resonance, states of vigilance and mentation. Neuroscience 2000; 101:243-276
7.
Smythies J: The functional neuroanatomy of awareness: with a focus on the role of various anatomical systems in the control of intermodal attention. Conscious Cogn 1997; 6:455-481

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 2113-a - 2114

History

Published online: 1 December 2002
Published in print: December 2002

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HARPREET S. DUGGAL, M.D., D.P.M.
Pittsburgh, Pa.

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