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Published Online: 1 September 2010

Response to Rickels Letter

Roy H. Perlis, M.D., M.SC.Authors Info & Affiliations

Publication: American Journal of Psychiatry

https://doi.org/10.1176/appi.ajp.2010.1004047r

To the Editor: We thank Dr. Rickels for reminding us of his early and important work in this area, which further highlights the porousness of the double-blind study. Indeed, as we pointed out, some of these concepts date back more than 25 years. In a previous draft of our commentary, we remarked on the curious point that such concepts seem to be rediscovered every decade or so.

Dr. Rickels also asserts his belief that alternative strategies, such as multiple raters or active placebos, will not be effective in preserving the blind. Certainly, one size does not fit all in a clinical trial design. However, given that existing trial design guidelines advocate these strategies, we might hope for an empirical study before dismissing them out of hand.

Footnote

accepted for publication in May 2010.

References

International Conference of Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use: ICH Harmonised Tripartite Guideline: Choice of Control Group and Related Issues in Clinical Trials (E10). Geneva, Switzerland, 2000. http://www.ich.org/LOB/media/MEDIA486.pdf

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 167 • Number 9 • September 2010

Pages: 1129

PubMed: 20826864

History

Accepted: May 2010

Published online: 1 September 2010

Published in print: September 2010

Authors

Details

Roy H. Perlis, M.D., M.SC.

Boston, Mass.

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Funding Information

The author's disclosures accompany the original commentary.

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Response to Rickels Letter

Footnote

References