Dopamine Synthesis Capacity Before Onset of Psychosis: A Prospective [18F]-DOPA PET Imaging Study
Abstract
Objective:
Method:
Results:
Conclusions:
Method
Participants
Clinical Measures
PET Scanning
Image Analysis
Region-of-interest analysis.
Voxel-based analysis.
Statistical Analysis
Results
Demographic and Clinical Characteristics
Healthy Comparison Group (N=29) | Psychotic Transition Group (N=9) | Nontransition Group (N=15) | ||||
---|---|---|---|---|---|---|
Characteristic | Mean | SD | Mean | SD | Mean | SD |
Age (years) | 25.6 | 4.0 | 24.9 | 3.1 | 23.8 | 3.7 |
Parental socioeconomic statusb | 3.0 | 0.9 | 2.9 | 0.9 | 3.0 | 0.9 |
Cigarettes/day | 2.8 | 5.2 | 5.2 | 5.8 | 5.2 | 5.5 |
Alcohol (units/week) | 10.0 | 10.5 | 6.5 | 6.8 | 4.8 | 4.6 |
Comprehensive Assessment of At-Risk Mental Statec | ||||||
Total score | 40.3 | 22.1 | 35.1 | 20.3 | ||
Positive score | 8.1 | 3.0 | 7.4 | 4.1 | ||
Positive and Negative Syndrome Scale | ||||||
Total score | 50.2 | 21.9 | 44.5 | 12.7 | ||
Positive score | 13.8 | 5.7 | 11.4 | 3.3 | ||
Global Assessment of Functioning scale score | 56.0 | 11.3 | 59.6 | 14.2 |
Striatal Dopamine Synthesis Capacity
Comparison Between the Psychotic Transition and Healthy Comparison Groups
Comparison Between the Psychotic Transition and Nontransition Groups
Comparison Between the Nontransition and Healthy Comparison Groups
The Relationship Between Striatal Dopamine Synthesis Capacity and Symptoms
Striatal Dopamine Synthesis Capacity in the Schizotypal Personality Disorder Group
Discussion
Findings in the Schizotypal Personality Disorder Group
Methodological Considerations
Specificity of the Findings
Acknowledgments
Footnote
Supplementary Material
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