Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies
Abstract
Objective
Method
Results
Conclusions
Method
Samples
Characteristic | GENDEP | MARS | STAR*D (Level 1) | |||
---|---|---|---|---|---|---|
N | % | N | % | N | % | |
Participants included in meta-analysis | 672 | 604 | 980 | |||
Participants treated with selective serotonin reuptake inhibitors (SSRIs) | 374 | 56 | NAb | 980 | 100 | |
Female | 429 | 64 | 326 | 54 | 580 | 59 |
Valid outcomes for at least 4 weeks of treatment | 597 | 89 | 532 | 88 | 943 | 96 |
Remission by week 12 | 270 | 46 | 253 | 47 | 330 | 35 |
Partial response at week 2 | 256 | 38 | 400 | 67 | 268 | 27 |
Mean | SD | Mean | SD | Mean | SD | |
Age (years) | 41.9 | 11.7 | 48.4 | 14.0 | 43.6 | 13.2 |
Baseline 17-item Hamilton Depression Rating Scale score | 22.4 | 4.7 | 25.1 | 5.6 | 21.3 | 5.1 |
Percentage change on primary measure over first 2 weeks of treatment | 21.1 | 22.3 | 35.0 | 26.4 | 23.9 | 23.6 |
Percentage change on primary measure over 12 weeks of treatment | 55.5 | 30.7 | 63.7 | 27.8 | 56.5 | 28.1 |
Common Inclusion Criteria
Phenotype Definition
Genotyping and Imputation
Statistical Analysis and Power
Results
Meta-Analyses
Primary outcomes: improvement and remission with up to 12 weeks of antidepressant treatment in the entire sample
Secondary outcomes: early improvement and partial response after 2 weeks of treatment in the entire sample
12-week outcomes with SSRIs
2-week outcomes with SSRIs
Discussion
Footnotes
Supplementary Material
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