The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis
Abstract
Objective:
Method:
Results:
Conclusions:
Method
Study Identification and Selection
Statistical Analysis
Results
Included Studies
![](/cms/10.1176/appi.ajp.2017.17040472/asset/images/large/appi.ajp.2017.17040472f1.jpeg)
Characteristics of the Included Sample
Concomitant Medicationsa | |||||||
---|---|---|---|---|---|---|---|
Authors (Reference Number) | Total N | Included N | Setting | Control Treatment | Diagnosis | N | % |
Berman et al. (10) | 8 | 5 | Outpatient | Saline | Major depression | 0 | 0 |
Valentine et al. (23) | 11 | 4 | Outpatient | Saline | Major depression | 0 | 0 |
Sos et al. (22) | 27 | 9 | Inpatient | Saline | Major depression | 9 | 100 |
Murrough et al. (14) | 73 | 35 | Inpatient/ outpatientb | Midazolam | Major depression | 0 | 0 |
Feder et al. (20) | 41 | 5 | Inpatient/ outpatientb | Midazolam | Posttraumatic stress disorder | 0 | 0 |
Ballard et al.c (15) | 87 | 59 | Inpatient | Saline | Major depression or bipolar disorder | 26 | 44 |
Hu et al. (21) | 27 | 26 | Outpatient | Saline | Major depression | 26 | 100 |
Murrough et al. (17) | 24 | 24 | Inpatient/ outpatient | Midazolam | Mixedd | 19 | 79 |
Total | 298 | 167 | 80 | 48 |
The Effects of Ketamine on Clinician-Administered Suicidal Ideation Item Scores
![](/cms/10.1176/appi.ajp.2017.17040472/asset/images/large/appi.ajp.2017.17040472f2.jpeg)
![](/cms/10.1176/appi.ajp.2017.17040472/asset/images/large/appi.ajp.2017.17040472f3.jpeg)
The Effects of Ketamine on Self-Reported Suicidal Ideation
![](/cms/10.1176/appi.ajp.2017.17040472/asset/images/large/appi.ajp.2017.17040472f4.jpeg)
Correlation Between Suicidal Ideation and Severity of Depressive Symptoms
Independence of Improvement Measures for Suicidal Ideation and Change in Severity of Depressive Symptoms
Durability of Effect
Midazolam Versus Saline as Control Treatment
Discussion
Pseudospecificity
Limitations
Future Work
Conclusions
Acknowledgments
Supplementary Material
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