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Published Online: 9 October 2024

Identifying Genetically Inferred Effects Linking Posttraumatic Stress Disorder to Women’s Health, Lipid Disorders, and Malaria Medications

Gita A. Pathak, Ph.D., Frank R. Wendt, Ph.D., Adam X. Maihofer, Ph.D., Posttraumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Kerry J. Ressler, M.D., Ph.D., Murray B. Stein, M.D., M.P.H., Karestan C. Koenen, Ph.D., Caroline M. Nievergelt, Ph.D., and Renato Polimanti, Ph.D. [email protected]Authors Info & Affiliations
Publication: American Journal of Psychiatry
Preprint
https://doi.org/10.1176/appi.ajp.20230832
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Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Preprint
PubMed: 39380377

History

Received: 18 October 2023
Revision received: 3 April 2024
Revision received: 20 May 2024
Published online: 9 October 2024

Keywords

  1. Posttraumatic Stress Disorder (PTSD)
  2. Genetics/Genomics
  3. Women

Authors

Details

Gita A. Pathak, Ph.D.
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Frank R. Wendt, Ph.D.
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Adam X. Maihofer, Ph.D.
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Posttraumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Kerry J. Ressler, M.D., Ph.D.
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Murray B. Stein, M.D., M.P.H.
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Karestan C. Koenen, Ph.D.
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Caroline M. Nievergelt, Ph.D.
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Renato Polimanti, Ph.D. [email protected]
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Pathak, Wendt, Polimanti); Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Pathak, Polimanti); Department of Anthropology, University of Toronto, Toronto, Ont. (Wendt); Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont. (Wendt); University of California San Diego, Department of Psychiatry, La Jolla, Calif. (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego (Maihofer, Stein, Nievergelt); Veterans Affairs San Diego Healthcare System, Research Service, San Diego (Maihofer, Nievergelt); Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego (Stein); Harvard Medical School, Department of Psychiatry, Boston; McLean Hospital, Belmont, Mass. (Ressler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Wu Tsai Institute, Yale University, New Haven (Polimanti).
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Notes

Send correspondence to Dr. Polimanti ([email protected]).

Author Contributions

Dr. Pathak and Dr. Wendt contributed equally to this article.

Competing Interests

Dr. Polimanti has received payment for editorial work on the journal Complex Psychiatry, and he has received a research grant from Alkermes. Dr. Stein has served as a consultant for Acadia Pharmaceuticals, Actelion, Aptinyx, Atai Life Sciences, Boehringer Ingelheim, Bionomics, BioXcel Therapeutics, Clexio, Delix Pharmaceuticals, EmpowerPharm, Engrail Therapeutics, GW Pharmaceuticals, Janssen, Jazz Pharmaceuticals, and Roche/Genentech; he is a stockholder in EpiVario and Oxeia Biopharmaceuticals; and he has received payment for editorial work on the journals Depression and Anxiety, Biological Psychiatry, and UpToDate. Dr. Ressler has served as a consultant for Acer, Bionomics, BioXcel, Jazz Pharmaceuticals, and Takeda; he has served on scientific advisory boards for the Brain Research Foundation and Sage; and he has received research support from Alto Neuroscience, BrainsWay, and Takeda. The other authors report no financial relationships with commercial interests.

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