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This chapter serves as a primer on the recent advances in our understanding of neural function both in health and in disease. It is beyond the scope of this chapter to cover these important areas in extensive detail, and readers are referred to outstanding textbooks that are entirely devoted to the topic (Kandel 2013; Nestler et al. 2015; Squire 2013). Here, we focus on the principles of neurotransmission that are critical for an understanding of the biological bases of major psychiatric disorders, as well as the mechanisms by which effective treatments may exert their beneficial effects. In particular, our goal is to lay the groundwork for the subsequent chapters in this volume that focus on individual disorders and their treatments.
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