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Chapter 18.Bupropion

Edited by:
https://doi.org/10.1176/appi.books.9781615371624.as18

Sections

History and Discovery | Structure–Activity Relations | Pharmacological Profile | Pharmacokinetics and Disposition | Mechanism of Action | Indications and Efficacy | Side Effects and Toxicology | Drug–Drug Interactions | Conclusion | References

Excerpt

Bupropion was discovered 50 years ago when investigators were searching for an antidepressant with a novel mechanism of action and safer side-effect profile compared with the antidepressants available at that time. Synthesized in 1966, this unique compound, different from the tricyclic antidepressants (TCAs) and the monoamine oxidase inhibitors (MAOIs), was found to have antidepressant activity in animal models that are predictive of antidepressant activity in humans (Soroko and Maxwell 1983).

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