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Chapter 37.Valproate

Edited by:
https://doi.org/10.1176/appi.books.9781615371624.as37

Sections

History and Discovery | Pharmacological Profile | Pharmacokinetics and Disposition | Mechanism of Action | Indications and Efficacy | Predictors of Positive Response to Valproate Versus Lithium | Side Effects and Toxicology | Drug–Drug Interactions | Conclusion | References

Excerpt

Valproate was the first mood stabilizer to be studied as an alternative to lithium (Lambert et al. 1966). An enteric-coated formulation, divalproex sodium, was approved in the United States for the treatment of mania in 1995. An extended-release (ER) formulation of divalproex was approved for migraine in 2001 and for mania in 2006. Valproate, either as divalproex or as other formulations, is now approved worldwide for the treatment of mania.

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