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Chapter 40.Lamotrigine

Edited by:
https://doi.org/10.1176/appi.books.9781615371624.as40

Sections

History and Discovery | Structure–Activity Relations and Pharmacological Profile | Pharmacokinetics and Disposition | Mechanism of Action | Indications and Efficacy | Dosing Recommendations | Side Effects and Toxicity | Drug–Drug Interactions | Conclusion | References

Excerpt

During the clinical development of lamotrigine as a treatment for intractable seizures, improved mood in lamotrigine-treated patients was anecdotally reported (Jawad et al. 1989; Smith et al. 1993). In 1993, the addition of lamotrigine to an existing antiepileptic drug regimen was evaluated in a small study of 81 patients with epilepsy (Smith et al. 1993). Lamotrigine-treated patients reported significantly higher levels of happiness and an improvement in perceived internal locus of control. There was no correlation between perceived happiness and changes in seizure frequency or severity. Thus, the investigators preliminarily concluded that lamotrigine may have an effect on mood independent of its antiepileptic effect.

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