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Published Online: 1 January 2012

Depression During the Menopausal Transition: An Update on Epidemiology and Biological Treatments

Luciano Minuzzi, M.D., Ph.D., Benicio N. Frey, M.D., Ph.D., and Claudio N. Soares, M.D., Ph.D., FRCPC [email protected]Authors Info & Affiliations

Publication: FOCUS

Volume 10, Number 1

https://doi.org/10.1176/appi.focus.10.1.22

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Abstract

The menopausal transition is often marked by physical symptoms (e.g., vasomotor and sexual) and is sometimes accompanied by emotional changes that follow the decline in ovarian functioning. Although the absolute majority of women experience a smooth transition into postmenopausal years, this period in a woman's life has been associated, in some cases, with higher risk to develop depressive symptoms. Recent evidence supports the notion that the transition may also constitute a “window of vulnerability” for some women to develop new-onset or recurrent depression. Serotonergic and noradrenergic antidepressants as well as transdermal estradiol have been shown to be effective in alleviating depressive and vasomotor symptoms in symptomatic, midlife women. In this review, the authors discuss the epidemiology of depression during the menopausal transition and update the current biological treatment strategies used to manage this condition in midlife women.

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Information & Authors

Information

Published In

FOCUS

Volume 10 • Number 1 • Winter 2012

Pages: 22 - 27

History

Published online: 1 January 2012

Published in print: Winter 2012

Authors

Details

Luciano Minuzzi, M.D., Ph.D.

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Benicio N. Frey, M.D., Ph.D.

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Claudio N. Soares, M.D., Ph.D., FRCPC [email protected]

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Notes

Address correspondence to Claudio N. Soares, M.D., Ph.D., FRCPC, Academic Head, Mood Disorders Division; Director, WHCC, 301 James St. South, FB 638, Hamilton, ON L8P 3B6, Canada; e-mail: [email protected]

Funding Information

Author Information and CME Disclosure

Luciano Minuzzi, M.D., Ph.D., Women's Health Concerns Clinic, McMaster University & St. Joseph's Healthcare, Hamilton, Ontario.

Dr. Minuzzi reports no competing interests.

Benicio N. Frey, M.D., Ph.D., Women's Health Concerns Clinic, McMaster University & St. Joseph's Healthcare, Hamilton, Ontario.

Dr. Frey reports: Speaker Fees: Bristol-Myers Squibb; Research Support: Eli Lilly Canada; Research and Travel Support: Pfizer Pharmaceuticals.

Claudio N. Soares, M.D., Ph.D., FRCPC, Professor and Associate Chair, Dept. of Psychiatry and Behavioural Neurosciences; Academic Head, Mood Disorders Division; Director, Women's Health Concerns Clinic, McMaster University & St. Joseph's Healthcare, Hamilton, Ontario.

Dr. Soares reports: Consutlant: Pfizer, Lundbeck, AstraZeneca, Bristol Myers Squibb, Moven Pharmaceuticals; Research Grants: Pfizer, Eli Lily, AstraZeneca, Bristol Myers Squibb, NARSAD, CIHR; Speaker's Bureau: PFizer, Lundbeck, AstraZeneca.

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Depression During the Menopausal Transition: An Update on Epidemiology and Biological Treatments

Abstract

Abstract

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