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Published Online: 25 January 2022

Ultrasound as a Neurotherapeutic: A Circuit- and System-Based Interrogation

Norman M. Spivak, B.S. https://orcid.org/0000-0002-2386-2987 [email protected], William Jamie Tyler, Ph.D., Ausaf A. Bari, M.D., Ph.D., and Taylor P. Kuhn, Ph.D.Authors Info & Affiliations

Publication: FOCUS

Volume 20, Number 1

https://doi.org/10.1176/appi.focus.20210022

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Abstract

Focused ultrasound is a novel brain stimulation modality that combines the noninvasiveness of repetitive transcranial magnetic stimulation and the precision of deep brain stimulation. In this review, the authors examine low-intensity focused ultrasound for brain mapping and neuromodulation. They also discuss high-intensity focused ultrasound, which is used for incisionless surgeries, such as capsulotomies for obsessive-compulsive disorder. Future potential applications of focused ultrasound are also presented.

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Information & Authors

Information

Published In

FOCUS

Volume 20 • Number 1 • Winter 2022

Pages: 32 - 35

History

Published in print: Winter 2022

Published online: 25 January 2022

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Authors

Details

Norman M. Spivak, B.S. https://orcid.org/0000-0002-2386-2987 [email protected]

UCLA-Caltech Medical Scientist Training Program (Spivak), Department of Neurosurgery, David Geffen School of Medicine (Spivak, Bari), and Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (Spivak, Kuhn), University of California, Los Angeles; School of Biological and Health Systems Engineering, Arizona State University, Tempe (Tyler).

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William Jamie Tyler, Ph.D.

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Ausaf A. Bari, M.D., Ph.D.

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Taylor P. Kuhn, Ph.D.

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Notes

Send correspondence to Mr. Spivak ([email protected]).

Competing Interests

Dr. Tyler reports being a cofounder of ISenseTec, LLC, and an inventor on issued and pending patents covering noninvasive neuromodulation methods and devices. The other authors report no financial relationships with commercial interests.

Funding Information

This work was funded by grant 5T32GM008042 to Mr. Spivak from the National Institute of General Medical Sciences.

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Ultrasound as a Neurotherapeutic: A Circuit- and System-Based Interrogation

Abstract

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