There are many opportunities for assessment-informed behavioral medicine interventions for the management of concerns that may result from COVID-19. Evidence-based translational behavioral medicine refers to interventions with scientific evidence for effectiveness or efficacy that promote physical and mental health or prevent illness (or both) (
62). A wide spectrum of evidence-based techniques and interventions offer potential applications for many COVID-19 concerns, including acute or lingering symptoms, fatigue, and sleep disruption, among others. Such interventions are commonly used in the treatment of mental health or psychosocial concerns as stand-alone treatments, or in combination with pharmacological or other nonpharmacological approaches.
Because of the broad applications of behavioral medicine across providers and settings, it is important to emphasize interventions that are brief and can be integrated into existing care (
17). Although behavioral medicine interventions were originally designed to be delivered in face-to-face settings, the field has been a leader in incorporating technology into interventions, starting early on with its focus on biofeedback to the present day, when it is common for behavioral medicine techniques to utilize wearable technology or be delivered virtually (
63). Moreover, although behavioral medicine interventions were also initially more focused on individual-level behavior change, a broader view that more fully incorporates sociocultural factors, such as the role of systemic oppression of marginalized groups on enduring global health disparities, has been emphasized in recent years (
64).
Given that many of the ongoing symptoms and concerns of COVID-19 are postexertional, an understanding of envelope theory (
65) or spoon theory (
66) models can also be useful for patients. These models assert that, often when patients are having better days with fewer symptoms, they will overexert themselves, leading to adverse symptoms postexertion (
37). Many individuals experiencing symptoms may not be knowledgeable about long-haul COVID, and thus mental health professionals can play a valuable role in providing education, validation, and support that the experience of ongoing symptoms are being seen in many other patients and that there are health behavior approaches that can help (
67).
Numerous techniques are widely used in behavioral medicine and clinical health psychology settings. Cognitive-behavioral therapy (CBT) and motivational interviewing (MI) are among the most common (
17). However, the list of possible interventions is vast and includes acceptance and commitment therapy (ACT) and other modalities such as biofeedback, mindfulness, and relaxation training. A brief overview of these interventions that may be adapted for COVID-19 concerns is provided in the following sections. For each, it is important to remember that the individual’s existing comorbid conditions, symptoms, treatments, roles (e.g., frontline health care worker, caregiver to a loved one), emotional-psychosocial health, and cultural context will affect both the individual’s experience of the symptoms and necessary adaptations to treatments.
Cognitive-Behavioral Therapy
CBT is perhaps the most widely adopted behavioral medicine intervention strategy, with a strong evidence base supporting its utility for numerous physical and mental health–related problems. Best characterized as a goal-driven, time-limited approach, CBT targets the relationships among thoughts, feelings, and behaviors, with a focus on the effect of maladaptive thought patterns (e.g., catastrophizing) on behaviors (e.g., withdrawal) and functioning (e.g., ability to perform daily activities) (
68). That is, CBT presumes that many presenting concerns are at least partially due to having learned a particular behavioral pattern because of specific cognitive and environmental contingencies (
69).
Treatment typically focuses on strategies to change both thought and behavioral patterns that perpetuate the presenting concerns, and it has been shown to be extremely effective in many populations (
69), including those seeking management of medical concerns (
70). Common CBT techniques include tracking (i.e., self-monitoring and charting specific thoughts and behaviors), increasing awareness of maladaptive thought patterns and situational factors, modifying these unhelpful thoughts and contexts, behavioral activation (i.e., scheduling and performing specific, meaningful activities), coping skills training, exposure (i.e., repeatedly facing a memory, situation, or physical sensation), role playing, and relaxation techniques (
69). CBT also requires the patient to be actively involved in their treatment and to consistently practice learned skills outside of therapy sessions to achieve a desired level of improvement in symptoms and functioning (
69).
Decades of research support the effectiveness of CBT for numerous applications that are relevant to COVID-19 symptoms. CBT has been applied to numerous facets of pain, including acute pain (
71), arthritis (
72), cancer (
73), other types of chronic pain (
74), and headache (
75), with some positive outcomes. To this end, specific techniques for pain management typically focus on pain education, pleasant activity scheduling (identifying meaningful activities and plans to manage barriers to participation), activity pacing (maintaining consistent activity levels with regular rest intervals to avoid overactivity), relaxation training, and coping skills training (
76). For taste and smell disorders, primary treatments typically focus on olfactory retraining (
77,
78), and there are not formally proposed CBT applications for these concerns. However, protocols for adjustment to distressing symptoms in other chronic health conditions may be useful, with an emphasis on psychoeducation, coping skills training, changing attentional focus, and relaxation (
79). Moreover, given the connection between taste and olfactory problems with psychological functioning (
36), CBT may ultimately be best applied on mental health sequelae, of which there is significant evidence. Similarly, CBT is not considered a first-line treatment for cognitive impairment, but lessons learned from dysfunction in attention and executive functioning in other chronic diseases (
80) provide potential directions for applications in the context of COVID-19. Given that other symptoms (e.g., depression, anxiety, disordered sleep) are known to be related to cognition, and there has been some documentation of this with regard to COVID-19 (
81), multidisciplinary approaches that incorporate CBT techniques for mental health and sleep (discussed later) are warranted.
There is also support for CBT, especially with physical exercise, in improving symptoms of fatigue in a number of chronic health conditions, including cancer (
82), multiple sclerosis (
83), and other types of postviral fatigue such as chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME) (
84). Some recommendations have been made for managing COVID-19–related fatigue using CBT based on CFS-ME protocols. These emphasize optimizing rest, relaxation training, education around energy conservation, and targeting cognitive (e.g., catastrophizing) and behavioral (e.g., overexertion to the point of exhaustion followed by prolonged underexertion) patterns (
37).
CBT for insomnia (CBT-I) is a subtype of CBT designed to treat sleep-related concerns in a range of populations with medical morbidities (
85). Protocols typically include a combination of sleep hygiene education, relaxation techniques, sleep restriction (strategies to reduce amount of time awake while in bed), challenging maladaptive cognitions (e.g., frustration about sleeping, labeling oneself as a “bad sleeper”) and feelings (e.g., worry around bedtime), and altering behaviors (e.g., lying awake in bed, checking the time) that perpetuate sleep disruption (
57). Although the evidence for CBT-I is compelling, especially for insomnia, there are barriers to its dissemination, including cost and the limited number of practitioners who are trained to deliver the treatment relative to the number of people living with sleep disorders (
86). A stepped-care approach to sleep problems has been proposed, utilizing technology to enable self-led management of sleep using CBT principles before referring to more formal, expert-delivered interventions (
87).
Motivational Interviewing
Clinicians may use MI either as a part of a CBT protocol or separately. MI is a patient-centered conversational style that seeks to increase and strengthen the internal motivation and empowerment needed to promote behavior change through the identification and exploration of ambivalence (
88). Clinicians utilizing MI collaborate with patients, rather than directing them, and engage using a nonjudgmental, nonconfrontational, encouraging style (
88). In contrast to CBT, there are not direct attempts to change maladaptive thoughts or behaviors in MI; rather, the clinician subtly encourages patients to notice and experience discrepancies between their current behavior and their goals (
88).
MI has been shown to be effective for numerous targets in health care settings, with even a single session demonstrating benefit in enhancing motivation to reach health-related goals (
89). Specific techniques that are commonly used include open-ended questions, affirmations (i.e., acknowledgment of patient strengths, efforts, and expertise), and reflective listening (i.e., empathetically summarizing patient statements) (
88). Although MI has primarily been used for COVID-19 vaccine hesitancy (
90), there are certainly other avenues for application, particularly as a vehicle to motivate treatment seeking and adherence. For example, MI has demonstrated such benefits in samples with pain (
91), fatigue (
92), and other chronic health conditions (
93), which suggests opportunities for COVID-19 treatment applications as well.
Acceptance and Commitment Therapy
Although CBT’s emphasis on challenging maladaptive thought patterns and behavioral activation can be useful in many settings, ACT offers a valuable alternative especially for some patients in health settings who may find CBT’s focus on challenging thoughts as invalidating to their lived experience. ACT is considered a “third wave” therapy that grew out of traditional CBT with a primary focus on psychological flexibility and the acceptance of difficult thoughts, feelings, experiences, and behaviors to commit to actions that are aligned with values and goals (
94). Unlike CBT, which promotes active change, ACT emphasizes that an event itself (e.g., a thought, grief, fear, illness, bodily sensation) may not be eliminated or changed and that attempts to do so are counterproductive (
94). Rather, the focus is on shifting one’s perspective about the event and concurrently engaging in values-consistent behavior that supports growth and meaning despite the adverse event (
94). ACT has yielded positive outcomes in medical domains, especially for addressing health behavior, pain, and anxiety, among others (
95,
96). To achieve these outcomes, ACT includes techniques such as mindfulness (focus on the moment rather than ruminating on past or future), defusion (observing events nonjudgmentally and not trying to control them), acceptance of discomfort, values exploration (identifying hopes and goals that matter most), and committed action to behaviors in alignment with values (
94).
ACT is potentially more acceptable than CBT for some patients who are managing acute or lingering symptoms, given its shift in emphasis from controlling or reducing symptoms to a greater flexibility in living a value-driven life, even in the presence of uncomfortable symptoms. Indeed, ACT has been found to be effective in chronic pain contexts on numerous outcomes, including increasing pain acceptance, pain tolerance, flexibility, and functioning (
97). Web-based ACT has also been successfully used for chronic pain (
98), which could increase accessibility to this therapeutic approach. There have also been promising applications for ACT to mitigate cancer-related fatigue (
99) and postviral CFS-ME fatigue (
100), pointing to the potential feasibility of ACT for COVID-19 fatigue. Sleep has rarely been studied from an ACT lens, but acceptance-based approaches have been proposed for managing related concerns (
101), and there is some evidence that ACT improves sleep when more traditional CBT-I approaches have not been effective (
102). Similarly, there is less work on other symptoms and concerns relevant to COVID-19, but there has been some support for the utility of ACT in other long-term health conditions (
103). Although the low number of high-quality studies in this area bars consensus recommendations for the application of ACT in these contexts (
103), it is certainly an avenue for opportunity in behavioral medicine practice and may be strongly considered for COVID-19 concerns, particularly if a patient sees the ACT framework as appealing.
Other Modalities
Numerous other techniques may be applied in the COVID-19 context as stand-alone treatments or within one of the aforementioned therapeutic protocols. Biofeedback is a mind-body technique that provides patients with biological feedback (e.g., heart rate variability, blood pressure, respiration) to increase awareness of the connection between thoughts and physical symptoms to subsequently enhance control over physiological symptoms, especially those exacerbated by stress (
104). Mindfulness is an intentional awareness of the present moment without judgment (
105). Numerous relaxation training and stress management techniques have also been developed, including diaphragmatic breathing (an exercise aimed at taking deep breaths with focused awareness on breathing) (
106), visualization and guided imagery (clinician-, self-, or audio-guided description of peaceful mental images or experiences) (
107), progressive muscle relaxation (systematically tensing and releasing various muscle groups) (
108), and autogenic training (repeating a series of statements about heaviness, warmth, relaxation, and bodily temperature to influence autonomic nervous system reactivity) (
109). Combining these therapies with physical activity has also been found to be more effective in improving symptoms than stand-alone relaxation or even cognitive techniques (
110); this suggests a pertinent role of physical activity as a potential adjunct to any of these modalities.