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Abstract

Polycystic ovary syndrome (PCOS) is one of the most prevalent gynecological endocrine conditions affecting reproductive women. It can feature a variety of symptoms, such as obesity, insulin resistance, skin conditions, and infertility. Women with PCOS are susceptible to illnesses including mood disorders, diabetes, hypertension, and dyslipidemia. Among them, depression is the most common in PCOS and has a detrimental effect on quality of life. Depression may occasionally develop due to the pathological traits of PCOS, but its exact pathogenesis in PCOS have eluded researchers to date. Therefore, there is an urgent need to explore the pathogenesis and treatments of depression in PCOS. The present review discusses the epidemiology of depression in PCOS, potential pathogenic mechanisms underlying PCOS and depression, as well as some potential factors causing depression in PCOS, including obesity, insulin resistance, hyperandrogenism, inflammation, and infertility. Meanwhile, some common treatment strategies for depression in PCOS, such as lifestyle intervention, acupuncture, oral contraceptive pills, psychological intervention, and insulin-sensitizer, are also reviewed. To fully understand the pathogenesis and treatment of depression in PCOS, a need remains for future large-scale multi-center randomized controlled trials and in-depth mechanism studies.
Appeared originally in Front Psychiatry 2022; 13:1001484

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History

Published in print: Winter 2024
Published online: 16 January 2024

Keywords

  1. polycystic ovary syndrome
  2. depression
  3. pathogenesis
  4. mechanism
  5. treatments

Authors

Details

Liwei Xing
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Jinlong Xu
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Yuanyuan Wei
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Yang Chen
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Haina Zhuang
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Wei Tang
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Shun Yu
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Junbao Zhang
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Guochen Yin
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Ruirui Wang [email protected]
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).
Dongdong Qin [email protected]
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Xing, Xu, Zhao), Department of TCM, Yunnan Maternal and Child Health Care Hospital, Kunming, China (Xu), School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China (Wei, Qin), Department of TCM, Hainan Women and Children’s Medical Center (Women and Children’s Health Care Center of Hainan Province, Hainan Children’s Hospital, Children’s Hospital of Fudan University at Hainan, Hainan Obstetrics and Gynecology Hospital), Haikou, China (Chen), Department of Journal Editorial, Yunnan University of Chinese Medicine, Kunming, China (Zhuang), Department of Acupuncture and Moxibustion, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China (Tang), The Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China (Yu, Zhang, Yin), School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Wang).

Notes

Correspondence: Dongdong Qin [email protected], Ruirui Wang [email protected] and Rong Zhao [email protected].

Competing Interests

Conflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Funding Information

Funding: This study was supported by the National Natural Science Foundation of China (31960178, 82160923, and 82060895), Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2019FA007), Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan Provincial Department of Education, Scientific Research Projects for High-level Talents of Yunnan University of Chinese Medicine (2019YZG01), Young Top-Notch Talent in 10,000 Talent Program of Yunnan Province (YNWR-QNBJ-2019-235), the Yunnan University of Chinese Medicine Joint Special Project of Applied Basic Research (2019FF002-004), and Yunnan Science and Technology Department Project (202103AC100005).

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