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Published Online: 1 January 2012

Longitudinal Evaluation of Neuropsychiatric Symptoms in Huntington's Disease

Jennifer C. Thompson, Ph.D., Jenny Harris, B.Sc., Andrea C. Sollom, M.A., Cheryl L. Stopford, Ph.D., Elizabeth Howard, MBChB, Julie S. Snowden, Ph.D., and David Craufurd, M.Sc.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 24, Number 1
https://doi.org/10.1176/appi.neuropsych.11030057
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Abstract

A group of 111 patients with Huntington's disease (HD) underwent a minimum of three annual neuropsychiatric assessments, using the Problem Behaviors Assessment for Huntington's Disease (PBA-HD). Longitudinal prevalence of neuropsychiatric symptoms was notably higher than baseline prevalence, suggesting that previous studies may have underestimated the extent of this clinical problem. Moreover, apathy, irritability, and depression were each associated with distinct longitudinal profiles. Apathy progressed over time and across disease stages. Irritability also increased significantly, but only in early stages of HD. Depression did not increase significantly at any stage of disease. The neuropsychiatric syndrome of apathy appears to be intrinsic to the evolution and progression of HD.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 24 • Number 1 • Winter 2012
Pages: 53 - 60
PubMed: 22450614

History

Received: 2 March 2011
Revision requested: 29 July 2011
Accepted: 16 August 2011
Published online: 1 January 2012
Published in print: Winter 2012

Keywords

  1. Huntington's Disease
  2. Neuropsychiatric Symptoms
  3. Longitudinal Evaluation
  4. Apathy
  5. Irritability
  6. Depression

Authors

Affiliations

Jennifer C. Thompson, Ph.D.
From the Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, Manchester, UK; Genetic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and St. Mary's Hospital, Central Manchester University Hospitals Foundation NHS Trust, Manchester, UK.
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Jenny Harris, B.Sc.
From the Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, Manchester, UK; Genetic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and St. Mary's Hospital, Central Manchester University Hospitals Foundation NHS Trust, Manchester, UK.
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Andrea C. Sollom, M.A.
From the Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, Manchester, UK; Genetic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and St. Mary's Hospital, Central Manchester University Hospitals Foundation NHS Trust, Manchester, UK.
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Cheryl L. Stopford, Ph.D.
From the Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, Manchester, UK; Genetic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and St. Mary's Hospital, Central Manchester University Hospitals Foundation NHS Trust, Manchester, UK.
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Elizabeth Howard, MBChB
From the Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, Manchester, UK; Genetic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and St. Mary's Hospital, Central Manchester University Hospitals Foundation NHS Trust, Manchester, UK.
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Julie S. Snowden, Ph.D.
From the Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, Manchester, UK; Genetic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and St. Mary's Hospital, Central Manchester University Hospitals Foundation NHS Trust, Manchester, UK.
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David Craufurd, M.Sc.
From the Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, Manchester, UK; Genetic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and St. Mary's Hospital, Central Manchester University Hospitals Foundation NHS Trust, Manchester, UK.
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Notes

Correspondence: Dr. Jennifer Thompson, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust; [email protected] (e-mail).

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