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Published Online: 1 April 2012

5-HT2 Receptor Distribution Shown by [18F] Setoperone PET in High-Functioning Autistic Adults

David Q. Beversdorf, M.D., Richard E. Nordgren, M.D., Ali A. Bonab, Ph.D., Alan J. Fischman, M.D., Ph.D., Steven B. Weise, Darin D. Dougherty, M.D. , Gretchen J. Felopulos, Ph.D., Feng C. Zhou, Ph.D., and Margaret L. Bauman, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 24, Number 2
https://doi.org/10.1176/appi.neuropsych.11080202
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Abstract

The serotonergic system is implicated in disordered emotional behavior. Autism is characterized by impaired processing of emotional information. The serotonergic (5-HT) system is also critically involved in brain development, and abnormal brain synthesis of serotonin is observed in autism. Furthermore, whole blood and platelet serotonin have been reported to be elevated in autism. The authors examined the CNS serotonin system in autism in vivo. 5-HT2 receptors were visualized by PET imaging of [18F]setoperone-binding in this pilot study of 6 high-functioning autistic adults and 10 matched-control participants. Autism subjects had less thalamic [18F]setoperone binding than controls, when covaried for age, but no difference reached significance in other areas. A negative relationship between thalamic binding and history of language impairment was also observed. Further studies will be needed to gain a clearer picture of the role of the 5-HT system in autism.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 24 • Number 2 • Spring 2012
Pages: 191 - 197
PubMed: 22772667

History

Received: 26 August 2011
Revision received: 9 December 2011
Accepted: 13 December 2011
Published online: 1 April 2012
Published in print: Spring 2012

Authors

Details

David Q. Beversdorf, M.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Richard E. Nordgren, M.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Ali A. Bonab, Ph.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Alan J. Fischman, M.D., Ph.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Steven B. Weise
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Darin D. Dougherty, M.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Gretchen J. Felopulos, Ph.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Feng C. Zhou, Ph.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Margaret L. Bauman, M.D.
From the Departments of Radiology, Neurology, and Psychological Sciences and the Thompson Center, University of Missouri (DQB); the Dept. of Pediatrics & Medicine (Neurology), Dartmouth Medical School (REN); the Dept. of Radiology, Division of Nuclear Medicine (AAB,AJF,SBW), Dept. of Psychiatry (DDD,GJF); and Dept. of Neurology (MLB), Massachusetts General Hospital; and the Depts. of Anatomy and Cell Biology, Indiana University School of Medicine (FCZ).
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Notes

Send correspondence to David Q. Beversdorf, M.D.; e-mail: [email protected]

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