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Published Online: 1 October 2012

A Randomized, Double-Blind Trial of Repetitive Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder With Three-Month Follow-Up

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Recent findings indicate that the motor and premotor cortices are hyperexcitable in obsessive-compulsive disorder (OCD). The authors have performed the first randomized, double-blind clinical trial of repetitive transcranial magnetic stimulation (rTMS) in OCD, with a 3-month follow-up. OCD patients (N=22) were assigned to either 2 weeks of active or sham rTMS to the supplementary motor area bilaterally. After 14 weeks, the response rate was 41% (7/12) with active and 10% (1/10) with sham treatment. At 14 weeks, patients receiving active rTMS showed, on average, a 35% reduction on the Y-BOCS, as compared with a 6.2% reduction in those receiving sham treatment.

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Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 437 - 443
PubMed: 23224449

History

Received: 10 October 2011
Revision received: 15 February 2012
Accepted: 16 April 2012
Published online: 1 October 2012
Published in print: Fall 2012

Authors

Details

Pablo Vinicius Oliveira Gomes, M.D.
From the Biology Institute, Laboratory of Neurosciences and Behavior, Brasilia University, Brasilia, Brazil (PVOG,JPBN,ERS), Movement Disorders Unit, Hospital de Base do Distrito Federal, Brasília, DF, Brazil (NA).
Joaquim Pereira Brasil-Neto, M.D., Ph.D.
From the Biology Institute, Laboratory of Neurosciences and Behavior, Brasilia University, Brasilia, Brazil (PVOG,JPBN,ERS), Movement Disorders Unit, Hospital de Base do Distrito Federal, Brasília, DF, Brazil (NA).
Nasser Allam, M.D., Ph.D.
From the Biology Institute, Laboratory of Neurosciences and Behavior, Brasilia University, Brasilia, Brazil (PVOG,JPBN,ERS), Movement Disorders Unit, Hospital de Base do Distrito Federal, Brasília, DF, Brazil (NA).
Everton Rodrigues de Souza, D.Psy.
From the Biology Institute, Laboratory of Neurosciences and Behavior, Brasilia University, Brasilia, Brazil (PVOG,JPBN,ERS), Movement Disorders Unit, Hospital de Base do Distrito Federal, Brasília, DF, Brazil (NA).

Notes

Send correspondence to Dr. de Souza; e-mail:[email protected]

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