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Clinical And Research Reports
Published Online: 1 April 2013

The Combined Treatment of Venlafaxine and Quetiapine for Treatment-Resistant Depression: A Clinical Study

Xiaoyi Li, M.D., Baoping Xing, Bachelor of Medicine, Enyan Yu, M.D., Wei Chen, Bachelor of Medicine, and Hao Wu, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 25, Number 2
https://doi.org/10.1176/appi.neuropsych.12070171
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Abstract

The authors studied the efficacy and safety of combined venlafaxine and quetiapine treatment for treatment-resistant depression (TRD) by dividing 95 TRD patients into two treatment groups: a combined venlafaxine (225 mg/day) and quetiapine (400 mg/day) group and a venlafaxine-only (225 mg/day) group for 8 weeks. Efficacy was assessed with the Hamilton Rating Scale for Depression, 17 items (Ham-D–17) and the Hamilton Rating Scale for Anxiety (Ham-A); safety was assessed with the Treatment-Emergent Symptom Scale (TESS). The two groups showed significant differences for the Ham-D–17 and Ham-A and no differences on the TESS. Combined venlafaxine and quetiapine treatment showed good efficacy and safety in TRD.

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Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 25 • Number 2 • Spring 2013
Pages: 157 - 160
PubMed: 23686035

History

Received: 12 July 2012
Accepted: 1 October 2012
Published online: 1 April 2013
Published in print: Spring 2013

Authors

Affiliations

Xiaoyi Li, M.D.
From the Dept. of Psychiatry and Mental Health, Tongde Hospital of Zhejiang Province, Hangzhou, China; The Mental Health Institute of Zhejiang Province, Hangzhou, China; Dept., of Psychiatry and Mental Health, The People’s Hospital of Zhejiang Province, Hangzhou, China; Dept. of Psychiatry and Mental Health, SIR RUN RUN SHAW Hospital, Zhejiang University School of Medicine, Hangzhou, China; SIR RUN RUN SHAW Institute of Clinical Medicine of Zhejiang University, Hangzhou, China.
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Baoping Xing, Bachelor of Medicine
From the Dept. of Psychiatry and Mental Health, Tongde Hospital of Zhejiang Province, Hangzhou, China; The Mental Health Institute of Zhejiang Province, Hangzhou, China; Dept., of Psychiatry and Mental Health, The People’s Hospital of Zhejiang Province, Hangzhou, China; Dept. of Psychiatry and Mental Health, SIR RUN RUN SHAW Hospital, Zhejiang University School of Medicine, Hangzhou, China; SIR RUN RUN SHAW Institute of Clinical Medicine of Zhejiang University, Hangzhou, China.
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Enyan Yu, M.D.
From the Dept. of Psychiatry and Mental Health, Tongde Hospital of Zhejiang Province, Hangzhou, China; The Mental Health Institute of Zhejiang Province, Hangzhou, China; Dept., of Psychiatry and Mental Health, The People’s Hospital of Zhejiang Province, Hangzhou, China; Dept. of Psychiatry and Mental Health, SIR RUN RUN SHAW Hospital, Zhejiang University School of Medicine, Hangzhou, China; SIR RUN RUN SHAW Institute of Clinical Medicine of Zhejiang University, Hangzhou, China.
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Wei Chen, Bachelor of Medicine
From the Dept. of Psychiatry and Mental Health, Tongde Hospital of Zhejiang Province, Hangzhou, China; The Mental Health Institute of Zhejiang Province, Hangzhou, China; Dept., of Psychiatry and Mental Health, The People’s Hospital of Zhejiang Province, Hangzhou, China; Dept. of Psychiatry and Mental Health, SIR RUN RUN SHAW Hospital, Zhejiang University School of Medicine, Hangzhou, China; SIR RUN RUN SHAW Institute of Clinical Medicine of Zhejiang University, Hangzhou, China.
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Hao Wu, M.D.
From the Dept. of Psychiatry and Mental Health, Tongde Hospital of Zhejiang Province, Hangzhou, China; The Mental Health Institute of Zhejiang Province, Hangzhou, China; Dept., of Psychiatry and Mental Health, The People’s Hospital of Zhejiang Province, Hangzhou, China; Dept. of Psychiatry and Mental Health, SIR RUN RUN SHAW Hospital, Zhejiang University School of Medicine, Hangzhou, China; SIR RUN RUN SHAW Institute of Clinical Medicine of Zhejiang University, Hangzhou, China.
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Notes

Send correspondence to Dr. Hao Wu, Dept. of Psychiatry and Mental Health, SIR RUN RUN SHAW Hospital, Zhejiang University School of Medicine, Hangzhou, China; e-mail: [email protected]

Funding Information

All authors declare no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work.

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