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Clinical and Research Reports
Published Online: 1 October 2013

Agomelatine Treatment of Major Depressive Disorder in Parkinson's Disease: A Case Series

Domenico De Berardis, M.D., Ph.D., Michele Fornaro, M.D., Nicola Serroni, M.D., Luigi Olivieri, M.D., Stefano Marini, M.D., Francesco Saverio Moschetta, M.D., Venkataramanujam Srinivasan, Ph.D., … Show All … , Maurizio Assetta, M.D., Alessandro Valchera, M.D., Anatolia Salone, M.D., Ph.D., Giovanni Martinotti, M.D., Ph.D., Marco Onofrj, M.D., and Massimo Di Giannantonio, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 25, Number 4
https://doi.org/10.1176/appi.neuropsych.12110286
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Abstract

Major Depressive Disorder (MDD) is among the most frequent comorbidities occurring in the course of Parkinson’s disease (PD), and therefore, most PD patients receive antidepressant drugs. Agomelatine is a recently introduced antidepressant drug acting as an MT1/MT2 melatonergic receptor agonist and 5HT2C/5HT2B serotonergic antagonist. The aim of this case series was to evaluate the role of agomelatine in the treatment of MDD associated with PD.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 25 • Number 4 • Fall 2013
Pages: 343 - 345
PubMed: 24247862

History

Received: 22 November 2012
Revision received: 21 March 2013
Accepted: 8 April 2013
Published online: 1 October 2013
Published in print: Fall 2013

Authors

Details

Domenico De Berardis, M.D., Ph.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Michele Fornaro, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Nicola Serroni, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Luigi Olivieri, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Stefano Marini, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Francesco Saverio Moschetta, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Venkataramanujam Srinivasan, Ph.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Maurizio Assetta, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Alessandro Valchera, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Anatolia Salone, M.D., Ph.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Giovanni Martinotti, M.D., Ph.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Marco Onofrj, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Massimo Di Giannantonio, M.D.
From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).
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Notes

Send correspondence to Dr. De Berardis; e-mail: [email protected]

Competing Interests

Conflicts of Interest and Source of Funding: The authors have no conflict of interest to declare.

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