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Published Online: 1 April 2014

Long-Term Neuropsychological Safety of Subgenual Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

Nicholas M. Bogod, Ph.D., R.Psych., Marci Sinden, B.A., Cindy Woo, B.A., Vanessa G. DeFreitas, M.A., Ivan J. Torres, Ph.D., R.Psych., Andrew K. Howard, M.D., F.R.C.P.C., Magdalena I. Ilcewicz-Klimek, M.D., F.R.C.P.C., Christopher R. Honey, M.D., F.R.C.S.C., Lakshmi N. Yatham, M.B.B.S., M.B.A. (Exec), and Raymond W. Lam, M.D., F.R.C.P.C.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 26, Number 2
https://doi.org/10.1176/appi.neuropsych.12110287
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Abstract

Deep brain stimulation of the subgenual cingulate gyrus is a promising investigational intervention for treatment-resistant depression (TRD), but long-term outcome data are limited. Serial neuropsychological evaluations, using a comprehensive battery, were conducted on four subjects with TRD prior to surgery, and up to 42 months post-operatively. Reliable change methodology suggested general stability and/or select statistically reliable improvement in cognitive abilities over time.

Abstract

Deep brain stimulation (DBS) of the subgenual cingulate gyrus (SCG) is a promising investigational intervention for treatment-resistant depression (TRD), but long-term outcome data are limited. Serial neuropsychological evaluations, using a comprehensive battery, were conducted on four subjects with TRD prior to surgery, and up to 42 months post-operatively. Reliable change methodology suggested general stability and/or select statistically reliable improvement in cognitive abilities over time. This is the first known set of multi-year neuropsychological follow-up data for SCG DBS for TRD. Observed improvements are likely attributable to reduced depressive symptomatology, recovery of functional capacities, and/or specific practice effects of repeated assessment.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 26 • Number 2 • Spring 2014
Pages: 126 - 133
PubMed: 24763760

History

Received: 22 November 2012
Revision received: 19 March 2013
Accepted: 26 March 2013
Published online: 1 April 2014
Published in print: Spring 2014

Authors

Affiliations

Nicholas M. Bogod, Ph.D., R.Psych.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Marci Sinden, B.A.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Cindy Woo, B.A.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Vanessa G. DeFreitas, M.A.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Ivan J. Torres, Ph.D., R.Psych.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Andrew K. Howard, M.D., F.R.C.P.C.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Magdalena I. Ilcewicz-Klimek, M.D., F.R.C.P.C.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Christopher R. Honey, M.D., F.R.C.S.C.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Lakshmi N. Yatham, M.B.B.S., M.B.A. (Exec)
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Raymond W. Lam, M.D., F.R.C.P.C.
From the Vancouver General Hospital (NMB, MS, CRH); Division of Neurology, Dept. of Medicine, University of British Columbia (NMB); Dept. of Psychiatry, University of British Columbia and UBC Hospital (CW, IJT, AKH, MII-K, LNY, RWL); Division of Neurosurgery, Dept. of Surgery, University of British Columbia and Vancouver General Hospital (CRH); Dept. of Psychology, Simon Fraser University (VGDF); BC Mental Health and Addictions Services (IJT); and Psychology, QEII Health Sciences Centre (VGDF).
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Notes

Send correspondence to Dr. Lam; e-mail: [email protected]

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