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Published Online: 1 October 2013

Psychiatric Presentation of Sporadic Creutzfeldt-Jakob Disease: A Challenge to Current Diagnostic Criteria

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Pathological diagnosis remains the gold standard for the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD), but being able to differentiate between CJD and non-prion diseases clinically is important because many of the non-prion, rapidly progressive dementias are treatable. Diagnostic criteria need both high sensitivity and specificity while remaining applicable to clinical practice. Despite extensive updates to the clinical criteria for sCJD, there remains a heavy emphasis on neurological signs. We describe a psychiatric presentation of sCJD that did not fulfill the diagnostic criteria until very late in a prolonged disease course and required biopsy for diagnosis.

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Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 335 - 338
PubMed: 24247860

History

Received: 7 February 2013
Revision received: 30 March 2013
Accepted: 17 April 2013
Published online: 1 October 2013
Published in print: Fall 2013

Authors

Details

Rehiana Ali, B.A., MB BChir (Cam), M.A., MRCP
From the Dept. of Medicine, Division of Experimental Medicine, Centre for Neuroscience, Imperial College, London, U.K., and the Walton Centre for Neurology and Neurosurgery, Liverpool, U.K.
Atik Baborie, M.D., FRCPath
From the Dept. of Medicine, Division of Experimental Medicine, Centre for Neuroscience, Imperial College, London, U.K., and the Walton Centre for Neurology and Neurosurgery, Liverpool, U.K.
Andrew J. Larner, M.D., MRCP
From the Dept. of Medicine, Division of Experimental Medicine, Centre for Neuroscience, Imperial College, London, U.K., and the Walton Centre for Neurology and Neurosurgery, Liverpool, U.K.
Richard White, M.D., MRCP
From the Dept. of Medicine, Division of Experimental Medicine, Centre for Neuroscience, Imperial College, London, U.K., and the Walton Centre for Neurology and Neurosurgery, Liverpool, U.K.

Notes

Send correspondence to Dr. R. Ali, Dept. of Medicine, Division of Experimental Medicine, Imperial College, London; e-mail: [email protected]

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