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Published Online: 26 February 2015

Regional Homogeneity of Resting-State Brain Abnormalities in Violent Juvenile Offenders: A Biomarker of Brain Immaturity?

Chen Chen, Ph.D., M.D., Jiansong Zhou, Ph.D., M.D., Chunhong Liu, Ph.D., M.D., Katrina Witt, D.Phil, B.A. (Hons.), Yingdong Zhang, Ph.D., M.D., Bin Jing, Ph.D., M.D., Chun Li, Ph.D., M.D., Xiaoping Wang, Ph.D., M.D., and Lingjiang Li, Ph.D., M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 27, Number 1
https://doi.org/10.1176/appi.neuropsych.13030044
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Abstract

The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 27 • Number 1 • Winter 2015
Pages: 27 - 32
PubMed: 25716485

History

Received: 3 March 2013
Revision received: 16 May 2013
Accepted: 19 June 2013
Published in print: Winter 2015
Published online: 26 February 2015

Authors

Affiliations

Chen Chen, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Jiansong Zhou, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Chunhong Liu, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Katrina Witt, D.Phil, B.A. (Hons.)
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Yingdong Zhang, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Bin Jing, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Chun Li, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Xiaoping Wang, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Lingjiang Li, Ph.D., M.D.
From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
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Notes

Send correspondence to Dr. Wang; e-mail: [email protected] or Dr. Zhou; e-mail: [email protected]

Funding Information

This work was supported by Key Projects in the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period (2012BAK16B04), the National Natural Science Foundation of China (NSFC, 30800368, 81371500), Ministry of Education in China Project of Humanities and Social Sciences (13YJC190033).The authors report no financial relationships with commercial interests.

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