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Published Online: 26 February 2015

The Psychiatric and Neuropsychiatric Symptoms After Subthalamic Stimulation for Parkinson’s Disease

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for the motor symptoms of Parkinson’s disease (PD). Nonmotor features of PD, however, may not improve with STN DBS, and a specific constellation of neuropsychiatric symptoms may emerge in the postoperative period. Mania, impulsivity, depression, and apathy may curtail the potential gains from surgery. In this paper, the authors discuss surgical candidacy, postoperative management of neuropsychiatric issues, and clinical dilemmas for the psychiatrist at the DBS center. A paradigm that considers stimulation effects and dopamine replacement therapy to be key drivers of postoperative neuropsychiatric problems is presented.

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Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 19 - 26
PubMed: 25716484

History

Received: 1 April 2014
Accepted: 6 May 2014
Published in print: Winter 2015
Published online: 26 February 2015

Authors

Details

Philip E. Mosley, M.A., B.M.B.Ch.
From the The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia; Dept. of Psychiatry, Royal Brisbane & Women’s Hospital, Herston, Queensland, Australia; and Neurosciences Queensland, St Andrew’s War Memorial Hospital, Spring Hill, Queensland, Australia
Rodney Marsh, M.B.B.S., F.R.A.N.Z.C.P.
From the The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia; Dept. of Psychiatry, Royal Brisbane & Women’s Hospital, Herston, Queensland, Australia; and Neurosciences Queensland, St Andrew’s War Memorial Hospital, Spring Hill, Queensland, Australia

Notes

Send correspondence to Philip E. Mosley, M.A.; e-mail: [email protected]

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