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Published Date: 22 February 2016

Psychiatric Symptoms in the Initial Motor Stage of Parkinson's Disease

Iva Stanković, M.D., Elka Stefanova, M.D., Ph.D., Aleksandra Tomić, M.D., Milica Ječmenica Lukić, M.D., Tanja Stojković, M.D., Vladana Marković, M.D., Gorana Mandić Stojmenović, M.D., Nikola Kresojević, M.D., Marina Svetel, M.D., Ph.D., and Vladimir Kostić, M.D., Ph.D.Authors Info & Affiliations

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 28, Number 3

https://doi.org/10.1176/appi.neuropsych.15100244

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Abstract

Neuropsychiatric symptoms (NPS) are common in Parkinson’s disease (PD). The aim of this study was to estimate the correlates of NPS in patients with PD in the initial motor stage of the disease (hemiparkinsonism). A total of 111 patients with PD and 105 healthy control participants were assessed. Patients with PD experienced apathy, depression, and anxiety more frequently compared with healthy controls. Sleep disturbances occurred commonly in early PD patients. Patients with PD and mild cognitive impairment (MCI) had depression and anxiety more frequently, but not apathy, compared with patients with PD without MCI. The results of this study confirm a high burden of NPS even in the earliest motor stage of PD.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences

Go to The Journal of Neuropsychiatry and Clinical Neurosciences

The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 28 • Number 3 • Summer 2016

Pages: 205 - 210

PubMed: 26900739

History

Received: 4 October 2015

Revision received: 15 November 2015

Accepted: 21 November 2015

Published online: 22 February 2016

Published in print: Summer 2016

Authors

Details

Iva Stanković, M.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Elka Stefanova, M.D., Ph.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Aleksandra Tomić, M.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Milica Ječmenica Lukić, M.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Tanja Stojković, M.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Vladana Marković, M.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Gorana Mandić Stojmenović, M.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Nikola Kresojević, M.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Marina Svetel, M.D., Ph.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Vladimir Kostić, M.D., Ph.D.

From Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia (IS, ES, AT, MJL, TS, VM, GMS, NK, MS, VK); and School of Medicine, University of Belgrade, Belgrade, Serbia (ES, MS, VK).

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Notes

Send correspondence to Dr. Kostić; e-mail: [email protected]

Competing Interests

Dr. Stefanova receives speaker’s honoraria from Novartis, Boehringer Ingelheim, Pfizer, and Lundbeck. Dr. Svetel receives speaker’s honoraria from Novartis, Boehringer Ingelheim, and GlaxoSmithKline. Dr. Kostić receives honoraria from Novartis, Boehringer Ingelheim, Pfizer, Lundbeck, GlaxoSmithKline, Swiss-Pharm, and Eurolek and a grant from SANU. All other authors report no financial relationships with commercial interests.

Funding Information

This work was supported by the Ministry of Education, Science, and Technological Development, Republic of Serbia (project no. 175090).

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