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Published Online: 17 November 2016

Transcranial Magnetic Stimulation Modulates Resting EEG Functional Connectivity Between the Left Dorsolateral Prefrontal Cortex and Limbic Regions in Medicated Patients With Treatment-Resistant Depression

Shinsuke Kito, M.D., Ph.D., Takashi Hasegawa, M.D., Ph.D., Akihiro Takamiya, M.D., Takamasa Noda, M.D., Kazuyuki Nakagome, M.D., Ph.D., Teruhiko Higuchi, M.D., Ph.D., and Yoshihiko Koga, M.D., Ph.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 29, Number 2
https://doi.org/10.1176/appi.neuropsych.15120419
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Abstract

High-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to have efficacy in treatment-resistant depression. However, the effects of rTMS on functional connectivity are still not clear. To examine changes in functional connectivity before and after rTMS, resting EEG of 14 patients with treatment-resistant depression was recorded twice at baseline and at week 4, respectively. The EEG data were analyzed using the standardized low-resolution brain electromagnetic tomography (sLORETA). The results reveal that high-frequency left prefrontal rTMS modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions, including the subgenual cingulate cortex and parahippocampal gyrus.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 29 • Number 2 • Spring 2017
Pages: 155 - 159
PubMed: 27852164

History

Received: 18 December 2015
Revision received: 24 July 2016
Revision received: 8 September 2016
Accepted: 21 September 2016
Published online: 17 November 2016
Published in print: Spring 2017

Keywords

  1. Depression
  2. Mood Disorders (Neuropsychiatric Aspects)
  3. Neurophysiology

Authors

Details

Shinsuke Kito, M.D., Ph.D.
From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
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Takashi Hasegawa, M.D., Ph.D.
From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
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Akihiro Takamiya, M.D.
From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
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Takamasa Noda, M.D.
From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
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Kazuyuki Nakagome, M.D., Ph.D.
From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
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Teruhiko Higuchi, M.D., Ph.D.
From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
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Yoshihiko Koga, M.D., Ph.D.
From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
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Notes

Send correspondence to Dr. Kito; e-mail: [email protected]

Competing Interests

The authors report no financial relationships with commercial interests.

Competing Interests

None of the authors have financial disclosures or conflicts of interest pertinent to the contents of this study.

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