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Published Online: 3 June 2016

Depression Symptoms in Chronic Left Hemisphere Stroke Are Related to Dorsolateral Prefrontal Cortex Damage

Kristopher Grajny, M.D., Harshini Pyata, Katherine Spiegel, B.A., Elizabeth H. Lacey, Ph.D., Shihui Xing, M.D., Ph.D., Carl Brophy, B.S., and Peter E. Turkeltaub, M.D., Ph.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 28, Number 4
https://doi.org/10.1176/appi.neuropsych.16010004
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Abstract

Damage to the brain’s mood regulation systems may contribute to poststroke depression. This study examines relationships between depression symptoms and psychosocial factors and then uses multivariate lesion-symptom mapping to localize depression symptoms in people with chronic left hemisphere stroke. Depression symptoms relate inversely to education and directly to physical disability. Damage in the left dorsolateral prefrontal cortex is associated with greater depression symptoms. These results demonstrate a neurological contribution to depression symptoms in chronic left hemisphere stroke and provide evidence of convergent biological mechanisms for poststroke depression symptoms and major depression with regard to left dorsolateral prefrontal cortex dysfunction.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 28 • Number 4 • Fall 2016
Pages: 292 - 298
PubMed: 27255855

History

Received: 8 January 2016
Revision received: 25 February 2016
Accepted: 23 March 2016
Published online: 3 June 2016
Published in print: Fall 2016

Authors

Details

Kristopher Grajny, M.D.
From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
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Harshini Pyata
From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
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Katherine Spiegel, B.A.
From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
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Elizabeth H. Lacey, Ph.D.
From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
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Shihui Xing, M.D., Ph.D.
From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
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Carl Brophy, B.S.
From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
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Peter E. Turkeltaub, M.D., Ph.D.
From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
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Notes

Send correspondence to Dr. Turkeltaub; e-mail: [email protected]

Competing Interests

The authors report no financial relationships with commercial interests.

Funding Information

The Vernon Family Trust:
National Center for Advancing Translational Sciences via the Georgetown-Howard Universities Center for Clinical and Translational Science: KL2TR000102
Project of Science and Technology New Star of Pearl River: 2012J2200089
Doris Duke Charitable Foundation10.13039/100000862: 2012062
National Natural Science Foundation of China10.13039/501100001809: 81000500
Supported by the Doris Duke Charitable Foundation (2012062), the National Center for Advancing Translational Sciences via the Georgetown-Howard Universities Center for Clinical and Translational Science (KL2TR000102), the National Natural Science Foundation of China (81000500), the Project of Science and Technology New Star of Pearl River (2012J2200089), and the Vernon Family Trust.

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