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Published Online: 31 August 2016

Onconeural Antibodies in Acute Psychiatric Inpatient Care

Sverre Georg Sæther, M.D., Morten Schou, M.D., Winfried Stoecker, M.D., Ph.D., Bianca Teegen, Ph.D., Kathrin Borowski, Arne Vaaler, M.D., Ph.D., Daniel Kondziella, M.D., Ph.D., and Solveig Klæbo Reitan, M.D., Ph.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 29, Number 1
https://doi.org/10.1176/appi.neuropsych.16050110
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Abstract

Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 29 • Number 1 • Winter 2017
Pages: 74 - 76
PubMed: 27578448

History

Received: 30 May 2016
Accepted: 2 June 2016
Published online: 31 August 2016
Published in print: Winter 2017

Keywords

  1. Neuroimmunology
  2. Organic Mental Disorders

Authors

Affiliations

Sverre Georg Sæther, M.D.
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Morten Schou, M.D.
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Winfried Stoecker, M.D., Ph.D.
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Bianca Teegen, Ph.D.
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Kathrin Borowski
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Arne Vaaler, M.D., Ph.D.
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Daniel Kondziella, M.D., Ph.D.
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Solveig Klæbo Reitan, M.D., Ph.D.
From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
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Notes

Send correspondence to Dr. Sæther; e-mail: [email protected]

Competing Interests

Dr. Stoecker is CEO of and shareholder with Euroimmun AG. Drs. Teegen and Borowski are employed by Euroimmun AG. All other authors report no financial relationships with commercial interests.

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