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Clinical Case Conference in Behavioral Neurology & Neuropsychiatry
Published Online: 16 October 2023

Case Study 6: The Diagnostic Challenge of a 75-Year-Old Man Who Had, Then Didn’t Have, Then Did Have Alzheimer’s Disease

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 325 - 332

History

Received: 6 June 2023
Revision received: 17 August 2023
Accepted: 18 August 2023
Published in print: Fall 2023
Published online: 16 October 2023

Keywords

  1. Alzheimer Disease
  2. Cognitive Disorders
  3. Dementia
  4. Limbic-Predominant Age-Related TDP-43 Encephalopathy
  5. Neurodegenerative Disorders
  6. Suspected Non-Alzheimer’s Pathophysiology

Authors

Affiliations

Sergio A. Ramírez-Salazar, M.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Cassie MacRae, M.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Mel B. Feany, M.D., Ph.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Michael Miller, M.D., Ph.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Hyun-Sik Yang, M.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Mary-Ellen Meadows, Ph.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Scott M. McGinnis, M.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
David Silbersweig, M.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Seth A. Gale, M.D.
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.
Kirk R. Daffner, M.D. [email protected]
Departments of Neurology (Ramírez-Salazar, Yang, Meadows, McGinnis, Gale, Daffner) and Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (MacRae, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School.

Notes

Send correspondence to Dr. Daffner ([email protected]).

Competing Interests

Dr. Silbersweig is cofounder and Scientific Advisory Board Chair of Ceretype Neuromedicine. The other authors report no financial relationships with commercial interests.

Funding Information

Supported in part by NIH grant K08AG065502 (to Dr. Miller), the Wimberly Family Clinical Care Research Fund, the Gaudet Family Research Fund, the Muss family and Mortimer/Grubman family, and the Herman F. Woerner Trust (to Dr. Daffner).

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